SYMPK and MIRLET7G

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SYMPK	MIRLET7G
Description		symplekin scaffold protein	microRNA let-7g
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cytoskeleton Plasma Membrane Bicellular Tight Junction Membrane Nuclear Body Anchoring Junction Nuclear Stress Granule	Extracellular Space RISC Complex
	Molecular Function	Protein Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Processing Cell Adhesion Negative Regulation Of Protein Binding	Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of SMAD Protein Signal Transduction Cellular Response To Glucose Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Asthma ( 31959851) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Colon cancer ( 28295283) Colorectal cancer ( 28295283) Coronary artery disease ( 29212778) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 23974872)
Interacting Genes		46 interacting genes: CSTF2 HSF1 HTT MIR1-2 MIR107 MIR128-2 MIR138-2 MIR155 MIR15B MIR16-2 MIR17 MIR18A MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR20B MIR21 MIR214 MIR25 MIR29A MIR34A MIR363 MIR7-2 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7D MIRLET7E MIRLET7G MIRLET7I RIN3 RNF10 SUMO2 TOP1 TRIM55 TRIM63 UBE2I YBX3	116 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CCAR1 CDC40 CDC5L CELF1 CHERP CPSF1 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PAXBP1 PDCD11 PLOD1 PLRG1 PTBP1 PTCD3 PUF60 PUM1 PUM2 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM12B RBM14 RBM17 RBM4 RBM4B RBM5 RBM6 RBMS1 RTCA RTCB SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR
Entrez ID		8189	406890
HPRD ID		09090
Ensembl ID		ENSG00000125755	ENSG00000199150
Uniprot IDs		Q92797
PDB IDs		3O2Q 3O2S 3O2T 3ODR 3ODS 4H3H 4H3K 6V4X
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion MRNA Destabilization Regulation Of Metabolic Process RNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Translation Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Vasculature Development Negative Regulation Of Developmental Process Negative Regulation Of Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Endothelial Cell Migration Extracellular Space Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Negative Regulation Of Cell Communication	RNA Binding RNA Processing Nucleic Acid Binding RNA Metabolic Process MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleoplasm Regulation Of MRNA Metabolic Process Nucleus Catalytic Step 2 Spliceosome Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MiRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Translation MRNA 3'-UTR Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of RNA Stability Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process U2 SnRNP RNA Stabilization MRNA Stabilization Negative Regulation Of Translation Regulation Of Metabolic Process MiRNA Processing Protein-RNA Complex Assembly TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity U2-type Prespliceosome Assembly Negative Regulation Of Macromolecule Metabolic Process
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