SHARPIN and ITGA2

Number of citations of the paper that reports this interaction (PMID 21947080)
27

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SHARPIN	ITGA2
Gene Name		SHANK-associated RH domain interactor	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Cell Junction Dendrite LUBAC Complex	Nucleus Plasma Membrane Focal Adhesion Integrin Complex Cell Outer Membrane External Side Of Plasma Membrane Cell Surface Integrin Alpha2-beta1 Complex Axon Terminus Basal Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Polyubiquitin Binding Protein Complex Binding Identical Protein Binding	Virus Receptor Activity Integrin Binding Protein Binding Collagen Binding Collagen Receptor Activity Laminin Binding Metal Ion Binding Protein Heterodimerization Activity Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Mitochondrion Organization Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Inflammatory Response Protein Homooligomerization Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	Response To Hypoxia Positive Regulation Of Leukocyte Migration Substrate-dependent Cell Migration Hypotonic Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Cell Proliferation Response To Virus Organ Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Response To Organic Cyclic Compound Response To Amine Response To Muscle Activity Positive Regulation Of Smooth Muscle Cell Migration Viral Process Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of Cell Projection Organization Cell-substrate Adhesion Cellular Response To Hormone Stimulus Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Binding Response To L-ascorbic Acid Cell Adhesion Mediated By Integrin Collagen-activated Signaling Pathway Response To Drug Positive Regulation Of DNA Binding Skin Morphogenesis Establishment Of Protein Localization Positive Regulation Of Translation Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Positive Chemotaxis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Phagocytosis, Engulfment Hepatocyte Differentiation
Pathways			Syndecan interactions Platelet Adhesion to exposed collagen Axon guidance CHL1 interactions Laminin interactions ECM proteoglycans L1CAM interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ITGA1 ITGA2 ITGAD ITGAL ITGAM SHANK1 SHANK2 TXN2 UBC UBE2D3	12 interactors: ACTA1 AUP1 CD9 COL1A1 COL1A2 COL8A1 HSPG2 ITGB1 LAMA1 MMP1 RABIF SHARPIN
Entrez ID		81858	3673
HPRD ID		15463	01893
Ensembl ID		ENSG00000179526	ENSG00000164171
Uniprot IDs		Q6PJD5 Q9H0F6	P17301
PDB IDs		4EMO	1AOX 1DZI 1PQB 1V7P
Enriched GO Terms of Interacting Partners?		Integrin-mediated Signaling Pathway Activated T Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization T Cell Proliferation Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Response To Wounding Toll-like Receptor Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Leukocyte Proliferation Positive Regulation Of Immune System Process Vocalization Behavior Blood Coagulation Pattern Recognition Receptor Signaling Pathway Hemostasis Innate Immune Response-activating Signal Transduction Cell Communication Activation Of Innate Immune Response Cell-matrix Adhesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Adhesion Cellular Extravasation Regulation Of Body Fluid Levels Positive Regulation Of Phosphatase Activity Wound Healing Cell-substrate Adhesion Immune System Process Immune Response Regulation Of Immune System Process Leukocyte Migration Response To Stress Regulation Of Innate Immune Response Social Behavior Cell Proliferation Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Dephosphorylation Negative Regulation Of ERBB Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Neutrophil Chemotaxis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Neutrophil Migration Regulation Of DNA-templated Transcription In Response To Stress	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Blood Vessel Development Multicellular Organismal Macromolecule Metabolic Process Vasculature Development Multicellular Organismal Metabolic Process Organ Development Blood Coagulation Hemostasis Cardiovascular System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Leukocyte Migration Tissue Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Body Fluid Levels Wound Healing System Development Response To Wounding Protein Heterotrimerization Head Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Blood Vessel Morphogenesis Organ Morphogenesis Developmental Process Response To Abiotic Stimulus Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Adhesion Cellular Component Assembly Platelet Activation Response To Mechanical Stimulus Protein Trimerization Cellular Response To Nutrient Regulation Of Cell Adhesion Cartilage Development Involved In Endochondral Bone Morphogenesis Skin Development Locomotion Endochondral Ossification Cell Activation Skin Morphogenesis Brain Development Striated Muscle Tissue Development Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Angiogenesis
Tagcloud ?		1l chain composed conjugation consists deeply elusive fluorescein fret fungal gliotoxin hoil hoip hts ibr linear lubac malignancy metabolite modulator nemo ring searched selectively tb3 termini though throughput ubiquitin
Tagcloud (Difference) ?		1l chain composed conjugation consists deeply elusive fluorescein fret fungal gliotoxin hoil hoip hts ibr linear lubac malignancy metabolite modulator nemo ring searched selectively tb3 termini though throughput ubiquitin
Tagcloud (Intersection) ?