ITGA2 and COL1A2

Number of citations of the paper that reports this interaction (PMID 2156854)
17

Data Source:
HPRD (in vitro)

		ITGA2	COL1A2
Gene Name		integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	collagen, type I, alpha 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Integrin Complex Cell Outer Membrane External Side Of Plasma Membrane Cell Surface Integrin Alpha2-beta1 Complex Axon Terminus Basal Part Of Cell Perinuclear Region Of Cytoplasm	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Collagen Binding Collagen Receptor Activity Laminin Binding Metal Ion Binding Protein Heterodimerization Activity Collagen Binding Involved In Cell-matrix Adhesion	Extracellular Matrix Structural Constituent Protein Binding Protein Binding, Bridging Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Migration Substrate-dependent Cell Migration Hypotonic Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Cell Proliferation Response To Virus Organ Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Response To Organic Cyclic Compound Response To Amine Response To Muscle Activity Positive Regulation Of Smooth Muscle Cell Migration Viral Process Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of Cell Projection Organization Cell-substrate Adhesion Cellular Response To Hormone Stimulus Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Binding Response To L-ascorbic Acid Cell Adhesion Mediated By Integrin Collagen-activated Signaling Pathway Response To Drug Positive Regulation Of DNA Binding Skin Morphogenesis Establishment Of Protein Localization Positive Regulation Of Translation Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Positive Chemotaxis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Phagocytosis, Engulfment Hepatocyte Differentiation	Skeletal System Development Blood Vessel Development Receptor-mediated Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Blood Pressure Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Odontogenesis Skin Morphogenesis Leukocyte Migration Protein Heterotrimerization Cellular Response To Amino Acid Stimulus
Pathways		Syndecan interactions Platelet Adhesion to exposed collagen Axon guidance CHL1 interactions Laminin interactions ECM proteoglycans L1CAM interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions	Platelet Adhesion to exposed collagen Collagen formation Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Syndecan interactions Crosslinking of collagen fibrils ECM proteoglycans GPVI-mediated activation cascade Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Platelet activation, signaling and aggregation Scavenging by Class A Receptors
Drugs
Diseases
GWAS			Aging ( 22773346) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Mean forced vital capacity from 2 exams ( 17903307)
Protein-Protein Interactions		12 interactors: ACTA1 AUP1 CD9 COL1A1 COL1A2 COL8A1 HSPG2 ITGB1 LAMA1 MMP1 RABIF SHARPIN	24 interactors: APP BGN CD36 CD44 CD93 COL5A3 DCN FN1 ITGA2 ITGA2B ITGB3 LIG4 LUM MMP9 MYOC P4HB PDGFA PDGFB SGTA SHBG SPARC TGFBI UBQLN1 VWF
Entrez ID		3673	1278
HPRD ID		01893	00363
Ensembl ID		ENSG00000164171	ENSG00000164692
Uniprot IDs		P17301	P08123
PDB IDs		1AOX 1DZI 1PQB 1V7P
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Blood Vessel Development Multicellular Organismal Macromolecule Metabolic Process Vasculature Development Multicellular Organismal Metabolic Process Organ Development Blood Coagulation Hemostasis Cardiovascular System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Leukocyte Migration Tissue Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Body Fluid Levels Wound Healing System Development Response To Wounding Protein Heterotrimerization Head Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Blood Vessel Morphogenesis Organ Morphogenesis Developmental Process Response To Abiotic Stimulus Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Adhesion Cellular Component Assembly Platelet Activation Response To Mechanical Stimulus Protein Trimerization Cellular Response To Nutrient Regulation Of Cell Adhesion Cartilage Development Involved In Endochondral Bone Morphogenesis Skin Development Locomotion Endochondral Ossification Cell Activation Skin Morphogenesis Brain Development Striated Muscle Tissue Development Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Angiogenesis	Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Blood Coagulation Wound Healing Hemostasis Platelet Activation Response To Wounding Regulation Of Body Fluid Levels Cell Activation Exocytosis Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Secretion By Cell Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-substrate Adhesion Secretion System Development Cell-matrix Adhesion Anatomical Structure Development Positive Regulation Of Epithelial Cell Migration Extracellular Matrix Disassembly Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Migration Chemotaxis Response To Stress Multicellular Organismal Development Developmental Process Regulation Of Cell Motility Organ Development Locomotion Regulation Of Locomotion Regulation Of Cellular Component Movement Glycosaminoglycan Catabolic Process Regulation Of Epithelial Cell Migration Response To External Stimulus Cell Development Response To Abiotic Stimulus Vesicle-mediated Transport Cell Projection Organization Anatomical Structure Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Response To Stimulus Regulation Of Cellular Amino Acid Metabolic Process Axon Guidance Leukocyte Migration Tissue Development Positive Regulation Of Metanephric Mesenchymal Cell Migration
Tagcloud ?			archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Difference) ?			archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Intersection) ?