ITGA2 and AUP1

Number of citations: 0 (PubMedID 12042322)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ITGA2	AUP1
Name		integrin subunit alpha 2	AUP1 lipid droplet regulating VLDL assembly factor
Structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Axon Integrin Alpha2-beta1 Complex Cell Projection Axon Terminus Basal Part Of Cell Perinuclear Region Of Cytoplasm Presynapse	Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Integrin Binding Protein Binding Collagen Binding Signaling Receptor Activity Collagen Receptor Activity Laminin Binding Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Migration Substrate-dependent Cell Migration Hypotonic Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Blood Coagulation Response To Xenobiotic Stimulus Animal Organ Morphogenesis Positive Regulation Of Epithelial Cell Migration Response To Amine Response To Muscle Activity Positive Regulation Of Smooth Muscle Cell Migration Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of Cell Projection Organization Cell-substrate Adhesion Positive Regulation Of Collagen Biosynthetic Process Response To L-ascorbic Acid Cell Adhesion Mediated By Integrin Collagen-activated Signaling Pathway Skin Morphogenesis Positive Regulation Of Translation Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Symbiont Entry Into Host Cell Focal Adhesion Assembly Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Phagocytosis, Engulfment Hepatocyte Differentiation Response To Parathyroid Hormone Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Cell-cell Adhesion	Response To Virus Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization ERAD Pathway Lipophagy Lipid Droplet Formation Protein Localization To Lipid Droplet
Pathways		Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans CHL1 interactions Platelet Adhesion to exposed collagen MET activates PTK2 signaling Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	None
GWAS		Acne (severe) ( 24927181 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Keratoconus ( 33649486 ) Mean platelet volume ( 32888494 ) Platelet distribution width ( 32888494 ) Type 2 diabetes ( 30130595 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: FBN2	None recorded
Interacting Genes		13 interacting genes: ACTA1 APP AUP1 CD9 COL1A1 COL1A2 COL8A1 HSPG2 ITGB1 LAMA1 MMP1 RABIF TSC22D2	10 interacting genes: GRSF1 ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11 UBC UBE2G2
Entrez ID		3673	550
HPRD ID		01893	03892
Ensembl ID		ENSG00000164171	ENSG00000115307
Uniprot IDs		P17301	Q9Y679
PDB IDs		1AOX 1DZI 1V7P 4BJ3 5HJ2 5THP 6ND8 6ND9 6NDA 6NDB 6NDC 6NDD 6NDE 6NDF 6NDG 6NDH	2EKF 7LEW
GO Terms Enriched among Interactors		Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Collagen Type I Trimer Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Space Integrin Binding Extracellular Region Regulation Of Spontaneous Synaptic Transmission Bone Trabecula Formation Collagen Metabolic Process Fibrillar Collagen Trimer Anatomical Structure Formation Involved In Morphogenesis Collagen Trimer Platelet-derived Growth Factor Binding Skin Morphogenesis Basement Membrane Anatomical Structure Morphogenesis Regulation Of Cell Migration Endoplasmic Reticulum Lumen Protein Trimerization Regulation Of Cell Motility Protease Binding Regulation Of Amyloid Fibril Formation Regulation Of Locomotion Regulation Of Neurotransmitter Uptake Low-density Lipoprotein Particle Receptor Binding Myoblast Fusion Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of Cell Adhesion Receptor-mediated Endocytosis Endocytosis Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Cell Adhesion Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Positive Regulation Of Cell Differentiation Extracellular Exosome Cellular Developmental Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Vitamin E Animal Organ Morphogenesis Protein Heterotrimerization Myoblast Fate Specification	Integrin Complex Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-substrate Adhesion Signaling Receptor Activity External Side Of Plasma Membrane Cell-cell Adhesion Cell Surface Cell Adhesion Mediated By Integrin Integrin Binding Heterotypic Cell-cell Adhesion Focal Adhesion Cell Adhesion Collagen Binding Involved In Cell-matrix Adhesion Virus Receptor Activity Wound Healing, Spreading Of Epidermal Cells Basal Part Of Cell Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Response To Muscle Activity Extracellular Matrix Binding Wound Healing, Spreading Of Cells Endodermal Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-substrate Junction Assembly Cell-substrate Junction Organization Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Extracellular Exosome Formation Of Primary Germ Layer Entry Into Host Cell By A Symbiont-containing Vacuole Opsonin Binding Angiogenesis Collagen Binding Integrin Alpha1-beta1 Complex Cell Migration Metal Ion Binding Amyloid-beta Binding Female Pregnancy Response To Activity Integrin Alpha5-beta1 Complex Integrin AlphaM-beta2 Complex Specific Granule Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Integrin Alphav-beta8 Complex