ITGA2

Gene Name		integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
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Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Integrin Complex Cell Outer Membrane External Side Of Plasma Membrane Cell Surface Integrin Alpha2-beta1 Complex Axon Terminus Basal Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Virus Receptor Activity Integrin Binding Protein Binding Collagen Binding Collagen Receptor Activity Laminin Binding Metal Ion Binding Protein Heterodimerization Activity Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Migration Substrate-dependent Cell Migration Hypotonic Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Cell Proliferation Response To Virus Organ Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Response To Organic Cyclic Compound Response To Amine Response To Muscle Activity Positive Regulation Of Smooth Muscle Cell Migration Viral Process Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of Cell Projection Organization Cell-substrate Adhesion Cellular Response To Hormone Stimulus Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Binding Response To L-ascorbic Acid Cell Adhesion Mediated By Integrin Collagen-activated Signaling Pathway Response To Drug Positive Regulation Of DNA Binding Skin Morphogenesis Establishment Of Protein Localization Positive Regulation Of Translation Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Positive Chemotaxis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Phagocytosis, Engulfment Hepatocyte Differentiation
Pathways		Syndecan interactions Platelet Adhesion to exposed collagen Axon guidance CHL1 interactions Laminin interactions ECM proteoglycans L1CAM interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-protein Interactions		12 interactors: ACTA1 AUP1 CD9 COL1A1 COL1A2 COL8A1 HSPG2 ITGB1 LAMA1 MMP1 RABIF SHARPIN
Entrez ID		3673
HPRD ID		01893
Ensembl ID		ENSG00000164171
Uniprot IDs		P17301
PDB IDs		1AOX 1DZI 1PQB 1V7P
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Blood Vessel Development Multicellular Organismal Macromolecule Metabolic Process Vasculature Development Multicellular Organismal Metabolic Process Organ Development Blood Coagulation Hemostasis Cardiovascular System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Leukocyte Migration Tissue Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Body Fluid Levels Wound Healing System Development Response To Wounding Protein Heterotrimerization Head Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Blood Vessel Morphogenesis Organ Morphogenesis Developmental Process Response To Abiotic Stimulus Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Adhesion Cellular Component Assembly Platelet Activation Response To Mechanical Stimulus Protein Trimerization Cellular Response To Nutrient Regulation Of Cell Adhesion Cartilage Development Involved In Endochondral Bone Morphogenesis Skin Development Locomotion Endochondral Ossification Cell Activation Skin Morphogenesis Brain Development Striated Muscle Tissue Development Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Angiogenesis
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