DVL3 and PDE6C

		DVL3	PDE6C
Description		dishevelled segment polarity protein 3	phosphodiesterase 6C
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GO Annotations	Cellular Component	Chromatin Cytoplasm Cytosol	Plasma Membrane Membrane Photoreceptor Disc Membrane
	Molecular Function	Protease Binding Signaling Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Small GTPase Binding	Nucleotide Binding 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Small GTPase-mediated Signal Transduction Response To Xenobiotic Stimulus Wnt Signaling Pathway Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Neuron Projection Arborization	Signal Transduction Visual Perception Phototransduction, Visible Light Retinal Cone Cell Development Sensory Perception Of Light Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs			Caffeine Trapidil
Diseases			Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)	Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Fasting glucose ( 34059833) Refractive error ( 32231278)
Interacting Genes		166 interacting genes: ABT1 ADAP1 AKAP17A ANKRD36B AP3M1 AXIN1 BAHD1 BEND7 BHLHE40 C1orf35 C8orf33 CBX8 CCDC33 CCNK CCNL1 CDYL2 CEP57L1 CEP70 CEP76 CLK1 CSNK1D CSNK1E CSNK2A1 CT45A10 CT45A3 CTNNB1 CYSRT1 DAB2 DDX54 DIDO1 DPPA2 DVL1 DYRK1A EIF1B EIF3D ENKD1 FAM13C FAM90A1 FARS2 FGF16 FLACC1 GADD45GIP1 HOMER3 HOXA5 HOXC5 HOXC8 INO80B KAT7 KAZN KCTD10 KCTD7 KLF1 KLF15 KLF3 KLF4 KLHL12 LENG8 LNX1 LONRF1 LRRK2 LUZP4 LY6H MAB21L3 MAGEB4 MAGOHB MARK2 MATN2 MBD1 NFYA NKD1 NOL12 NXF1 PATZ1 PHF19 PIK3CB PITX1 PLAGL2 PLN PNKP PPM1A PPP1R16B PPP2CA PRKAA2 PRPF18 PRPF3 PRPF31 PRPF38A PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSME3 PSMF1 RBM15B RBM39 RNF151 RPL11 RPS10 RRP8 RWDD2B SAP30L SHFL SNIP1 SNX22 SORBS3 STOM SUV39H1 SYT6 SYTL4 TBPL1 TCEA2 TCEANC TFG THAP7 TLE5 TNFAIP8L1 TNP1 TPTEP2-CSNK1E TRAF2 TRIM41 TRIM54 TSN TSPYL1 TSPYL6 UTP3 VANGL1 VAX1 WDR25 WT1 XPA YTHDC1 ZBTB24 ZBTB26 ZBTB47 ZBTB48 ZBTB8A ZFP57 ZNF165 ZNF2 ZNF264 ZNF319 ZNF408 ZNF417 ZNF441 ZNF444 ZNF497 ZNF512B ZNF552 ZNF581 ZNF648 ZNF696 ZNF697 ZNF699 ZNF71 ZNF764 ZNF774 ZNF775 ZNF792 ZNF821 ZNF837 ZRSR2 ZSCAN21 ZSCAN22 ZSCAN25	1 interacting genes: CDC42
Entrez ID		1857	5146
HPRD ID		03222	02898
Ensembl ID		ENSG00000161202	ENSG00000095464
Uniprot IDs		Q92997	P51160
PDB IDs		6V7O 6ZBQ 6ZBZ 6ZC3 6ZC4 6ZC6 6ZC7 6ZC8 8S6A	3JWQ 3JWR 5E8F 9CXG 9CXH 9CXI 9CXJ
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Wnt Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Speck Cellular Response To Endothelin Response To Endothelin Negative Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Epigenetic Regulation Of Gene Expression Wnt Signalosome Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm RNA Metabolic Process Chromatin Organization Nucleic Acid Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sequence-specific Double-stranded DNA Binding Heterochromatin Formation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Chromatin Remodeling U2-type Precatalytic Spliceosome Chromatin Silencing Complex Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Wnt Signaling Pathway Apolipoprotein A-I Receptor Binding Regulation Of Actin Cytoskeleton Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Actin Filament-based Process Small GTPase-mediated Signal Transduction Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Positive Regulation Of Cell Projection Organization Leading Edge Membrane Thioesterase Binding Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cytoskeleton Organization Positive Regulation Of MAPK Cascade Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Golgi Localization Regulation Of Neuron Projection Arborization Cardiac Conduction System Development Establishment Of Epithelial Cell Apical/basal Polarity Cell Migration Involved In Heart Development Dendritic Spine Morphogenesis Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Embryonic Heart Tube Development Intracellular Signaling Cassette Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Positive Regulation Of Lamellipodium Assembly Spindle Midzone Nuclear Migration Establishment Of Epithelial Cell Polarity
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