RNF170 and PLPP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF170	PLPP6
Description		ring finger protein 170	phospholipid phosphatase 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nuclear Envelope Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Lyase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Isoprenoid Diphosphate Phosphatase Activity
	Biological Process	Protein Polyubiquitination Adult Walking Behavior Response To Temperature Stimulus Gene Expression Proteasomal Protein Catabolic Process Response To Activity Protein Ubiquitination Protein Catabolic Process Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Protein K48-linked Ubiquitination Walking Behavior	Immune System Process Lipid Metabolic Process Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Protein Prenylation Geranyl Diphosphate Metabolic Process Innate Immune Response Farnesyl Diphosphate Catabolic Process Phospholipid Dephosphorylation Geranylgeranyl Diphosphate Catabolic Process Positive Regulation Of Neutrophil Activation
Pathways			Cholesterol biosynthesis
Drugs
Diseases
GWAS
Interacting Genes		15 interacting genes: DNAJC30 FXYD6-FXYD2 HACD1 PLPP6 PSMA6 SGTA SGTB SNAP47 STARD3 TMEM109 TMEM97 UBE2D2 UBE2L3 UBE2U UPK2	57 interacting genes: AMIGO1 AQP6 AQP8 BTN2A1 BTNL9 C16orf92 CD79A CIAO2A CLDN15 CLDN9 CLEC4M CLN5 COMT CREB3L1 EBP FAM174A FAM209A FAM210B FKBP7 FNDC9 FXYD3 GJB5 GKN1 GORAB GPX8 HSH2D IL10RA IL13RA2 KASH5 LAYN LDLRAD1 MMGT1 MS4A3 MUC1 NCR3LG1 PDGFRA PDZK1IP1 PHACTR3 PRLR PVR RETREG3 RNF170 RNF5 SEC11C SHISAL1 SIGLEC12 SLC7A14 SMAGP SOCS4 SSMEM1 STX1A SYNE4 SYNPR TMEM106C TMIE TNFRSF10D VSIR
Entrez ID		81790	403313
HPRD ID		13165	17397
Ensembl ID		ENSG00000120925	ENSG00000205808
Uniprot IDs		Q96K19	Q8IY26
PDB IDs
Enriched GO Terms of Interacting Partners?		TRC Complex Ubiquitin Conjugating Enzyme Activity Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin-like Protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Purine Ribonucleoside Triphosphate Binding Establishment Of Protein Localization To Membrane Protein Targeting Cholesterol Binding Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process	Membrane
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