RNF170 and FXYD6-FXYD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF170	FXYD6-FXYD2
Description		ring finger protein 170	FXYD6-FXYD2 readthrough
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Adult Walking Behavior Response To Temperature Stimulus Gene Expression Proteasomal Protein Catabolic Process Response To Activity Protein Ubiquitination Protein Catabolic Process Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Protein K48-linked Ubiquitination Walking Behavior
Pathways
Drugs
Diseases
GWAS			Hippocampal volume in Alzheimer's disease dementia ( 29274321)
Interacting Genes		15 interacting genes: DNAJC30 FXYD6-FXYD2 HACD1 PLPP6 PSMA6 SGTA SGTB SNAP47 STARD3 TMEM109 TMEM97 UBE2D2 UBE2L3 UBE2U UPK2	34 interacting genes: APH1B APOL3 AQP6 AVPR2 BEST1 BNIP3 CERS4 CLDN5 ERGIC3 FAM210B GPR152 GPR37L1 GPRC5D MTIF3 PGRMC2 RNF170 SLC10A1 SLC10A6 SLC16A13 SLC19A3 SLC2A13 SLC34A2 SLC35H1 SLC7A8 SPCS1 TLCD4 TMEM14B TMEM167B TMEM205 TMEM41A TMPPE TMX2 TRHR UNC93A
Entrez ID		81790	100533181
HPRD ID		13165
Ensembl ID		ENSG00000120925	ENSG00000255245
Uniprot IDs		Q96K19	A0A087WZ82 A0A0A6YYL5
PDB IDs
Enriched GO Terms of Interacting Partners?		TRC Complex Ubiquitin Conjugating Enzyme Activity Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin-like Protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Purine Ribonucleoside Triphosphate Binding Establishment Of Protein Localization To Membrane Protein Targeting Cholesterol Binding Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process	Membrane Transmembrane Transport Bile Acid:sodium Symporter Activity Symporter Activity Organic Anion Transport Renal Water Transport Carboxylic Acid Transport Organic Acid Transport Protein Binding Organic Hydroxy Compound Transport Endoplasmic Reticulum G Protein-coupled Receptor Activity Bile Acid And Bile Salt Transport
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