TSSK3 and EYA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSSK3	EYA2
Description		testis specific serine kinase 3	EYA transcriptional coactivator and phosphatase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cilium Motile Cilium Sperm Flagellum Cell Projection	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Metal Ion Binding Protein Serine Kinase Activity	Magnesium Ion Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Histone H2AXY142 Phosphatase Activity
	Biological Process	Protein Phosphorylation Spermatogenesis Spermatid Development Cell Differentiation	DNA Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Mesodermal Cell Fate Specification Striated Muscle Tissue Development Cell Differentiation Positive Regulation Of DNA Repair Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Pre-treatment viral load in HIV-1 infection ( 31219150)	A body shape index ( 34021172) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 31361310) Asthma ( 32296059) Body fat percentage and triglycerides (pairwise) ( 33619380) Brain volume in infants (intracranial brain volume) ( 28763065) Coffee consumption ( 31046077) Fasting insulin ( 34059833) FEV1 ( 30804560) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Lung function (FVC) ( 30804560 30061609) Non-del(5q) myelodysplastic syndromes ( 31738830) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30054458 30297969) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		67 interacting genes: ADAMTSL4 ARID5A ATP23 CATSPERT CENPN COXFA4L3 DDIT4L DRG2 ECSIT EFHC2 EYA2 FUT9 GOLGA2 GP2 IKZF3 INCA1 KRT75 KRTAP13-2 KRTAP13-3 LBX1 LHX3 LMO2 LNX1 LZTS2 MBD3L1 MEI4 MRPL28 MSX2 MYOG MYOZ3 NFKBID NME4 OIP5 PBX4 PJA1 PLEKHG4 PPP1R16A PRDM6 RBBP4 RBCK1 REL RIN3 RUSC1 SHISA6 SLAIN1 SMAD4 SPMIP6 STAT5B SYNGAP1 TCF4 TCP10L TEPSIN TGM7 TLE5 TRIM35 TRIM50 TRIM54 TRIM9 TRIP6 UROD USP54 VGLL1 VPS52 YJU2B YPEL3 ZBTB25 ZMYND12	36 interacting genes: AATK ATOSB BAG3 CATSPER1 CDK18 DMRTB1 DTX2 DUSP21 ENKD1 FBXO7 GNAI2 GNAZ HGS IQUB LGALS4 MED25 PATZ1 PAX9 PIN1 POGZ RBPMS RFX2 ROR2 SIX1 SIX4 SNRPC SPG21 SUOX TEKT4 TEKT5 TFG TLE5 TRAF4 TRAPPC6A TSSK3 VPS37C
Entrez ID		81629	2139
HPRD ID		09635	09041
Ensembl ID		ENSG00000162526	ENSG00000064655
Uniprot IDs		Q96PN8	E7ETN2 O00167
PDB IDs			3GEB 3HB0 3HB1 4EGC 5ZMA 7F8G 7F8H
Enriched GO Terms of Interacting Partners?		Protein Binding Transcription Regulator Complex	Sperm Flagellum Fungiform Papilla Morphogenesis Sperm Motility Motile Cilium Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Cellular Component Assembly Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Organelle Assembly Axonemal A Tubule Inner Sheath Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development Cilium Cilium Movement Cranial Ganglion Development Tongue Development Metanephric Mesenchyme Development Positive Regulation Of Epithelial Tube Formation Microtubule-based Movement Regulation Of Synaptic Assembly At Neuromuscular Junction Cilium Assembly Microtubule-based Process Myoblast Migration Reproductive Process Cilium Organization Ciliary Basal Body Vesicle Organization Ganglion Development Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Guanyl Nucleotide Binding Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Animal Organ Morphogenesis Pharyngeal System Development Generation Of Neurons Plasma Membrane Bounded Cell Projection Assembly Regulation Of Branching Involved In Ureteric Bud Morphogenesis Protein Targeting G-protein Beta/gamma-subunit Complex Binding Cell Projection Assembly Regulation Of Skeletal Muscle Cell Differentiation COPII Vesicle Coating Muscle Cell Cellular Homeostasis Protein Binding Cell Motility Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Muscle Cell Migration Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
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