TSSK3 and ZBTB25

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TSSK3	ZBTB25
Description		testis specific serine kinase 3	zinc finger and BTB domain containing 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cilium Motile Cilium Sperm Flagellum Cell Projection	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Metal Ion Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Spermatid Development Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process
Pathways
Drugs
Diseases
GWAS		Pre-treatment viral load in HIV-1 infection ( 31219150)	Heel bone mineral density ( 30598549) Lymphocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494)
Interacting Genes		67 interacting genes: ADAMTSL4 ARID5A ATP23 CATSPERT CENPN COXFA4L3 DDIT4L DRG2 ECSIT EFHC2 EYA2 FUT9 GOLGA2 GP2 IKZF3 INCA1 KRT75 KRTAP13-2 KRTAP13-3 LBX1 LHX3 LMO2 LNX1 LZTS2 MBD3L1 MEI4 MRPL28 MSX2 MYOG MYOZ3 NFKBID NME4 OIP5 PBX4 PJA1 PLEKHG4 PPP1R16A PRDM6 RBBP4 RBCK1 REL RIN3 RUSC1 SHISA6 SLAIN1 SMAD4 SPMIP6 STAT5B SYNGAP1 TCF4 TCP10L TEPSIN TGM7 TLE5 TRIM35 TRIM50 TRIM54 TRIM9 TRIP6 UROD USP54 VGLL1 VPS52 YJU2B YPEL3 ZBTB25 ZMYND12	33 interacting genes: APIP COIL CRACR2B CYP2J2 CYSRT1 DDIT3 FCGR3A FHL2 HCLS1 HOMEZ HSBP1 KCTD1 KCTD9 KRTAP10-8 KRTAP17-1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 SUMO2 TBC1D5 TNIP1 TRAF2 TRAF6 TSSK3 VCP VMAC ZBTB1
Entrez ID		81629	7597
HPRD ID		09635	01926
Ensembl ID		ENSG00000162526	ENSG00000089775
Uniprot IDs		Q96PN8	G3V2K3 P24278
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Transcription Regulator Complex	Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Post-translational Protein Modification CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of JUN Kinase Activity Interleukin-17-mediated Signaling Pathway Regulation Of Protein Deubiquitination Positive Regulation Of Protein Deubiquitination Amino Acid Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II MyD88-dependent Toll-like Receptor Signaling Pathway Signaling Adaptor Activity Protein Homooligomerization Negative Regulation Of DNA-templated Transcription Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Transcription Factor Binding Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Fc-epsilon Receptor Signaling Pathway Ubiquitin-like Protein Ligase Binding Regulation Of T Cell Mediated Immunity Translesion Synthesis Regulation Of Post-translational Protein Modification Regulation Of Programmed Cell Death Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of MAPK Cascade Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of T Cell Cytokine Production Protein Complex Oligomerization Arachidonate 5,6-epoxygenase Activity Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress TORC2 Complex Disassembly Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Flavin Adenine Dinucleotide Catabolic Process Positive Regulation Of Pro-T Cell Differentiation
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