TSSK3 and LHX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSSK3	LHX3
Description		testis specific serine kinase 3	LIM homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cilium Motile Cilium Sperm Flagellum Cell Projection	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Manganese Ion Binding Metal Ion Binding Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Spermatid Development Cell Differentiation	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation
Pathways			Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Pre-treatment viral load in HIV-1 infection ( 31219150)	Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 20189936 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in HIV infection ( 33109212) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 28166213) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)
Interacting Genes		67 interacting genes: ADAMTSL4 ARID5A ATP23 CATSPERT CENPN COXFA4L3 DDIT4L DRG2 ECSIT EFHC2 EYA2 FUT9 GOLGA2 GP2 IKZF3 INCA1 KRT75 KRTAP13-2 KRTAP13-3 LBX1 LHX3 LMO2 LNX1 LZTS2 MBD3L1 MEI4 MRPL28 MSX2 MYOG MYOZ3 NFKBID NME4 OIP5 PBX4 PJA1 PLEKHG4 PPP1R16A PRDM6 RBBP4 RBCK1 REL RIN3 RUSC1 SHISA6 SLAIN1 SMAD4 SPMIP6 STAT5B SYNGAP1 TCF4 TCP10L TEPSIN TGM7 TLE5 TRIM35 TRIM50 TRIM54 TRIM9 TRIP6 UROD USP54 VGLL1 VPS52 YJU2B YPEL3 ZBTB25 ZMYND12	80 interacting genes: ABI2 ACTN3 AIF1L ANKRD45 ANP32A ATP6V1G1 BYSL CATSPERT CCDC146 CCDC6 CDC23 CDK3 CITED2 CKS1B CLCNKA CPNE7 CSNK2A1 CWF19L2 DRC4 ENKD1 FAIM FAM124B FAM221A FIGLA GAS2L2 GCM2 GUCD1 HOXC5 HOXC8 IFT172 INCA1 INSC INTS4 IQUB ISL1 ISL2 KANK2 KLHL38 KRT3 LDB1 LDB2 LHX1 LMX1A MAPK9 NFIA NFIB NFIC NFKBID NRDE2 NRF1 NUDT22 OCRL PARP11 PARVG PNMA5 PRKAB2 PSMB1 PSORS1C2 QRICH1 RCOR3 RHBDF1 RLIM RUNX1T1 SAT1 SCNM1 SH2D1A SNRNP25 TAF1 TCEANC TEX14 TSEN54 TSSK3 UBTFL1 USP2 VEZF1 ZNF354C ZNF417 ZNF574 ZNF587 ZNF76
Entrez ID		81629	8022
HPRD ID		09635	02783
Ensembl ID		ENSG00000162526	ENSG00000107187
Uniprot IDs		Q96PN8	F1T0D5 F1T0D7 F1T0D9 Q9UBR4
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Transcription Regulator Complex	Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II LIM Domain Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuron Fate Specification Nucleus Cell Differentiation In Spinal Cord DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Central Nervous System Neuron Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Visceral Motor Neuron Differentiation Sequence-specific Double-stranded DNA Binding Nucleoplasm Transcription Regulator Complex Spinal Cord Motor Neuron Differentiation Cytoskeletal Anchor Activity DNA-templated Transcription RNA Metabolic Process RNA Polymerase I General Transcription Initiation Factor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Cell Population Proliferation Regulation Of Gene Expression Cyclin Binding Pattern Specification Process Chromatin Positive Regulation Of RNA Biosynthetic Process Cell Fate Specification Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Axis Specification Glial Cell Fate Specification Actin Filament Positive Regulation Of Smoothened Signaling Pathway Neural Tube Formation Regulation Of Macromolecule Biosynthetic Process Peripheral Nervous System Neuron Development
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