TRMT1L and PRPF6

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		TRMT1L	PRPF6
Description		tRNA methyltransferase 1L	pre-mRNA processing factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Centrosome Cytosol Membrane Nuclear Speck Ciliary Basal Body U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding TRNA (guanine) Methyltransferase Activity Transferase Activity Metal Ion Binding TRNA (guanine(27)-N2)-dimethyltransferase Activity	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	TRNA N2-guanine Methylation TRNA Processing Methylation	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Localization RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II
Pathways			mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Hand grip strength ( 29691431)	Body mass index ( 28552196) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: APP MIR106A MIR141 MIR17 MIR34A MIR93 PRPF6 SUMO2	67 interacting genes: AR ARAF BAG4 BICD2 C1orf35 CD2BP2 CEBPA CEP55 CLK2 CPSF7 CTBP1 CTTN DDX17 DMRTB1 EFTUD2 EHMT2 ESR1 EXOSC7 EXOSC8 FHIT FXR2 HNRNPLL HOOK1 IDH3A KIF24 KRT31 LARP4 LMNA MRPL1 MRPL44 MRPS11 NIN NME1 NR3C1 PCM1 PHF5A PPIE QKI RAF1 RBM22 RBPMS RNF10 RPL36AL RYBP SF3B4 SMARCA2 SNRNP200 SNRNP48 SNRNP70 SNRPA SNRPF SRRM2 SRSF2 SRSF8 SUMO2 SUN2 TFIP11 THOC1 TIMM44 TRAK1 TRMT1L TSNAXIP1 TXNL4B USO1 VIM YWHAB ZRSR2
Entrez ID		81627	24148
HPRD ID		12722	10729
Ensembl ID		ENSG00000121486	ENSG00000101161
Uniprot IDs		B4DXX1 Q7Z2T5	O94906
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Vascular Endothelial Growth Factor Production MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MRNA 3'-UTR Binding Post-transcriptional Gene Silencing Regulation Of Vascular Endothelial Growth Factor Production Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Extracellular Vesicle RISC Complex Regulation Of Chemokine Production Negative Regulation Of Chemokine Production Response To Norepinephrine Cellular Response To Norepinephrine Stimulus MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Cytokine Production Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Connective Tissue Replacement Regulation Of Cytokine Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Cholesterol Efflux Regulation Of Connective Tissue Replacement Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Translation Negative Regulation Of Glycoprotein Metabolic Process Cellular Response To Catecholamine Stimulus Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Amyloid-beta Clearance Response To Catecholamine Regulation Of Osteoblast Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Tissue Remodeling Negative Regulation Of Cholesterol Transport Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Interleukin-8 Production Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Catabolic Process Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process	RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Metabolic Process Nucleic Acid Binding Nuclear Speck Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Nucleoplasm Regulation Of RNA Splicing U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Protein Binding Identical Protein Binding U2-type Catalytic Step 2 Spliceosome U5 SnRNP Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Estrogen Response Element Binding Regulation Of MRNA Processing Microtubule Anchoring At Microtubule Organizing Center Spliceosomal Complex Assembly U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing U1 SnRNP Estrogen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Microtubule Anchoring U2-type Prespliceosome Assembly Protein-RNA Complex Assembly Nuclear Migration Regulation Of Alternative MRNA Splicing, Via Spliceosome U2 SnRNP Nuclear Matrix Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process U2-type Spliceosomal Complex Steroid Hormone Receptor Signaling Pathway
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