TRMT1L and MIR106A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		TRMT1L	MIR106A
Description		tRNA methyltransferase 1L	microRNA 106a
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus	Extracellular Space RISC Complex Extracellular Vesicle
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding TRNA (guanine) Methyltransferase Activity Transferase Activity Metal Ion Binding TRNA (guanine(27)-N2)-dimethyltransferase Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	TRNA N2-guanine Methylation TRNA Processing Methylation	Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-8 Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Vascular Endothelial Growth Factor Production
Pathways
Drugs
Diseases
GWAS		Hand grip strength ( 29691431)
Interacting Genes		8 interacting genes: APP MIR106A MIR141 MIR17 MIR34A MIR93 PRPF6 SUMO2	82 interacting genes: ADARB1 AIMP2 APOBEC3B AQR C1QBP DARS1 DDX1 DDX21 DDX3X DDX3Y DHX36 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FAM98B FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NONO NUDT21 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TIAL1 TRA2B TRMT1L U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346
Entrez ID		81627	406899
HPRD ID		12722
Ensembl ID		ENSG00000121486	ENSG00000284157
Uniprot IDs		B4DXX1 Q7Z2T5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Vascular Endothelial Growth Factor Production MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MRNA 3'-UTR Binding Post-transcriptional Gene Silencing Regulation Of Vascular Endothelial Growth Factor Production Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Extracellular Vesicle RISC Complex Regulation Of Chemokine Production Negative Regulation Of Chemokine Production Response To Norepinephrine Cellular Response To Norepinephrine Stimulus MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Cytokine Production Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Connective Tissue Replacement Regulation Of Cytokine Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Cholesterol Efflux Regulation Of Connective Tissue Replacement Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Translation Negative Regulation Of Glycoprotein Metabolic Process Cellular Response To Catecholamine Stimulus Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Amyloid-beta Clearance Response To Catecholamine Regulation Of Osteoblast Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Tissue Remodeling Negative Regulation Of Cholesterol Transport Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Interleukin-8 Production Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Catabolic Process Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleus Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleoplasm Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex Catalytic Step 2 Spliceosome Spliceosomal Complex Cytoplasmic Stress Granule MiRNA Binding MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization TRNA Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Regulation Of RNA Stability MRNA Stabilization Regulation Of Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Stability Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Gene Expression Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process P-body
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