TRMT1L and MIR141

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		TRMT1L	MIR141
Description		tRNA methyltransferase 1L	microRNA 141
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus	Extracellular Space RISC Complex
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding TRNA (guanine) Methyltransferase Activity Transferase Activity Metal Ion Binding TRNA (guanine(27)-N2)-dimethyltransferase Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	TRNA N2-guanine Methylation TRNA Processing Methylation	Positive Regulation Of Cell Population Proliferation MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Transformation Of Host Cell By Virus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways
Drugs
Diseases
GWAS		Hand grip strength ( 29691431)
Interacting Genes		8 interacting genes: APP MIR106A MIR141 MIR17 MIR34A MIR93 PRPF6 SUMO2	87 interacting genes: ADARB1 APOBEC3B C1QBP CPSF7 DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FAM98B FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP6 LARP7 LIN28A LRPPRC MARS1 MATR3 MSI2 MYEF2 NONO NUDT16L1 NUDT21 P3H1 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 QARS1 QKI RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2B TRMT1L UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H11A ZNF346
Entrez ID		81627	406933
HPRD ID		12722
Ensembl ID		ENSG00000121486	ENSG00000207708
Uniprot IDs		B4DXX1 Q7Z2T5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Vascular Endothelial Growth Factor Production MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MRNA 3'-UTR Binding Post-transcriptional Gene Silencing Regulation Of Vascular Endothelial Growth Factor Production Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Extracellular Vesicle RISC Complex Regulation Of Chemokine Production Negative Regulation Of Chemokine Production Response To Norepinephrine Cellular Response To Norepinephrine Stimulus MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Cytokine Production Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Connective Tissue Replacement Regulation Of Cytokine Production Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Glycoprotein Biosynthetic Process Negative Regulation Of Cholesterol Efflux Regulation Of Connective Tissue Replacement Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Translation Negative Regulation Of Glycoprotein Metabolic Process Cellular Response To Catecholamine Stimulus Regulation Of Amyloid Precursor Protein Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Amyloid-beta Clearance Response To Catecholamine Regulation Of Osteoblast Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Tissue Remodeling Negative Regulation Of Cholesterol Transport Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Interleukin-8 Production Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Translation Positive Regulation Of Catabolic Process Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Metabolic Process	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Nucleus Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Spliceosomal Complex Nucleoplasm Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Negative Regulation Of RNA Catabolic Process MiRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule MRNA 3'-UTR Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA Stabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation TRNA Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity MRNA 5'-UTR Binding Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Positive Regulation Of Gene Expression Regulation Of MRNA Stability RNA Transport Positive Regulation Of Cytoplasmic Translation Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Ligase Activity
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