UNC93B1 and SYNDIG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UNC93B1	SYNDIG1
Description		unc-93B1 regulator of TLR signaling	synapse differentiation inducing 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagocytic Vesicle	Endosome Plasma Membrane Postsynaptic Density Membrane Dendrite Synaptic Vesicle Membrane Early Endosome Membrane Cell Projection Dendritic Spine Dendritic Shaft Intracellular Membrane-bounded Organelle Cell Body Synapse Postsynaptic Membrane Excitatory Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Toll-like Receptor Binding	Protein Binding Glutamate Receptor Binding Protein Homodimerization Activity
	Biological Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process T Cell Antigen Processing And Presentation Intracellular Protein Transport Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus	Intracellular Protein Transport Positive Regulation Of Synapse Assembly Synaptic Vesicle Clustering Regulation Of Postsynapse Assembly
Pathways		Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE
Drugs
Diseases
GWAS		Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)	LDL cholesterol levels in HIV infection ( 33109212) Sucrose liking ( 31005972)
Interacting Genes		31 interacting genes: AQP6 BEST2 CCDC107 CD79A CFTR CLDN7 CLPTM1 CREB3L1 CYB5R3 EBP ERGIC3 FATE1 FFAR3 FKBP7 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35H1 SSMEM1 SYNDIG1 TM4SF18 TMEM237	16 interacting genes: AQP6 ELOVL4 FATE1 FFAR2 GPR42 GPRC5D LEPROTL1 MAL MFSD6 PFDN1 SLC16A13 SLC35H1 SLC41A1 TLCD4 TMEM43 UNC93B1
Entrez ID		81622	79953
HPRD ID		12191	12766
Ensembl ID		ENSG00000110057	ENSG00000101463
Uniprot IDs		Q9H1C4	Q9H7V2
PDB IDs		7C76 7CYN
Enriched GO Terms of Interacting Partners?		Membrane B Cell Receptor Complex Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Binding Endoplasmic Reticulum Membrane Steroid Biosynthetic Process Receptor Complex	Membrane
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