SYNDIG1 and UNC93B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYNDIG1	UNC93B1
Description		synapse differentiation inducing 1	unc-93B1 regulator of TLR signaling
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Postsynaptic Density Membrane Dendrite Synaptic Vesicle Membrane Early Endosome Membrane Cell Projection Dendritic Spine Dendritic Shaft Intracellular Membrane-bounded Organelle Cell Body Synapse Postsynaptic Membrane Excitatory Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagocytic Vesicle
	Molecular Function	Protein Binding Glutamate Receptor Binding Protein Homodimerization Activity	Protein Binding Toll-like Receptor Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Synapse Assembly Synaptic Vesicle Clustering Regulation Of Postsynapse Assembly	Cell Morphogenesis Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process T Cell Antigen Processing And Presentation Intracellular Protein Transport Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus
Pathways			Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE
Drugs
Diseases
GWAS		LDL cholesterol levels in HIV infection ( 33109212) Sucrose liking ( 31005972)	Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		16 interacting genes: AQP6 ELOVL4 FATE1 FFAR2 GPR42 GPRC5D LEPROTL1 MAL MFSD6 PFDN1 SLC16A13 SLC35H1 SLC41A1 TLCD4 TMEM43 UNC93B1	31 interacting genes: AQP6 BEST2 CCDC107 CD79A CFTR CLDN7 CLPTM1 CREB3L1 CYB5R3 EBP ERGIC3 FATE1 FFAR3 FKBP7 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35H1 SSMEM1 SYNDIG1 TM4SF18 TMEM237
Entrez ID		79953	81622
HPRD ID		12766	12191
Ensembl ID		ENSG00000101463	ENSG00000110057
Uniprot IDs		Q9H7V2	Q9H1C4
PDB IDs			7C76 7CYN
Enriched GO Terms of Interacting Partners?		Membrane	Membrane B Cell Receptor Complex Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Binding Endoplasmic Reticulum Membrane Steroid Biosynthetic Process Receptor Complex
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