UNC93B1 and FFAR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UNC93B1	FFAR3
Description		unc-93B1 regulator of TLR signaling	free fatty acid receptor 3
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GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagocytic Vesicle	Plasma Membrane Membrane
	Molecular Function	Protein Binding Toll-like Receptor Binding	G Protein-coupled Receptor Activity Protein Binding Lipid Binding
	Biological Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process T Cell Antigen Processing And Presentation Intracellular Protein Transport Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus	Immune System Process Mucosal Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Norepinephrine Secretion Positive Regulation Of Chemokine Production Negative Regulation Of Blood Pressure Regulation Of Insulin Receptor Signaling Pathway Regulation Of Hormone Biosynthetic Process Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion
Pathways		Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE	G alpha (q) signalling events Free fatty acid receptors
Drugs
Diseases
GWAS		Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		31 interacting genes: AQP6 BEST2 CCDC107 CD79A CFTR CLDN7 CLPTM1 CREB3L1 CYB5R3 EBP ERGIC3 FATE1 FFAR3 FKBP7 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35H1 SSMEM1 SYNDIG1 TM4SF18 TMEM237	13 interacting genes: CD79A COMT CTXN3 EFNA5 LAT LTC4S SERINC1 SLC41A1 TEX264 TOMM6 TREX1 UNC93B1 YIPF1
Entrez ID		81622	2865
HPRD ID		12191	04823
Ensembl ID		ENSG00000110057	ENSG00000185897
Uniprot IDs		Q9H1C4	A0A0K0PUW7 O14843
PDB IDs		7C76 7CYN	8J20 8J21
Enriched GO Terms of Interacting Partners?		Membrane B Cell Receptor Complex Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Binding Endoplasmic Reticulum Membrane Steroid Biosynthetic Process Receptor Complex	T Cell Antigen Processing And Presentation Membrane Adaptive Immune Response Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Norepinephrine Secretion Catechol O-methyltransferase Activity Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Endoplasmic Reticulum Membrane Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System
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