UNC93B1 and SLC16A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UNC93B1	SLC16A2
Description		unc-93B1 regulator of TLR signaling	solute carrier family 16 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagocytic Vesicle	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Toll-like Receptor Binding	Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Transmembrane Transporter Activity Identical Protein Binding Carboxylic Acid Transmembrane Transporter Activity
	Biological Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process T Cell Antigen Processing And Presentation Intracellular Protein Transport Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus	Amino Acid Metabolic Process Thyroid Hormone Generation Monocarboxylic Acid Transport Thyroid Hormone Metabolic Process Transmembrane Transport Thyroid Hormone Transport Thyroid-stimulating Hormone Secretion Amino Acid Import Across Plasma Membrane Transport Across Blood-brain Barrier Carboxylic Acid Transmembrane Transport Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE	Organic anion transport by SLCO transporters
Drugs			Pyruvic acid
Diseases			Allan-Herndon-Dudley syndrome; Monocarboxylate transporter 8 deficiency
GWAS		Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		31 interacting genes: AQP6 BEST2 CCDC107 CD79A CFTR CLDN7 CLPTM1 CREB3L1 CYB5R3 EBP ERGIC3 FATE1 FFAR3 FKBP7 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35H1 SSMEM1 SYNDIG1 TM4SF18 TMEM237	38 interacting genes: ADIPOQ ANKRD46 APOL3 BTN2A2 C3orf52 CCL2 CNIH3 COL4A5 CXCL16 CYB5B EFNA5 FAM3C JAGN1 LAT LEPROTL1 LHFPL5 LPAR3 MFSD6 MS4A13 PLP1 PNLIPRP1 SERPINA7 SLC30A2 SLC38A7 SLC39A13 SLC39A9 SMCO4 SYNGR1 THRA TMEM254 TMEM60 TOMM6 TRARG1 TSPO2 UNC93B1 UPK1B VAMP3 VEGFA
Entrez ID		81622	6567
HPRD ID		12191	02106
Ensembl ID		ENSG00000110057	ENSG00000147100
Uniprot IDs		Q9H1C4	P36021
PDB IDs		7C76 7CYN
Enriched GO Terms of Interacting Partners?		Membrane B Cell Receptor Complex Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Binding Endoplasmic Reticulum Membrane Steroid Biosynthetic Process Receptor Complex	Membrane Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Intracellular Zinc Ion Homeostasis Cytokine Activity Neutrophil Differentiation Myeloid Cell Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Protein Autophosphorylation Positive Regulation Of Cell Growth
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