UNC93B1 and LEUTX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UNC93B1	LEUTX
Description		unc-93B1 regulator of TLR signaling	leucine twenty homeobox
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagocytic Vesicle	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Toll-like Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding
	Biological Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process T Cell Antigen Processing And Presentation Intracellular Protein Transport Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE	Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS		Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)	Macular thickness ( 30535121)
Interacting Genes		31 interacting genes: AQP6 BEST2 CCDC107 CD79A CFTR CLDN7 CLPTM1 CREB3L1 CYB5R3 EBP ERGIC3 FATE1 FFAR3 FKBP7 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35H1 SSMEM1 SYNDIG1 TM4SF18 TMEM237	46 interacting genes: AGPAT4 AIG1 AQP2 AQP3 ASGR1 C1GALT1 C1QL4 C3orf52 CDS2 CMTM3 CMTM5 CNIH1 CNIH3 CXCL9 EMP3 ENTPD3 FAM24B FZD7 GOSR2 KIR2DL3 LAT MRPL57 MS4A1 NAPB NDRG4 OLFM4 PLP1 PNLIPRP1 PRB1 SLC13A3 SLC30A8 SLC41A2 STATH TF TMEM128 TMEM147 TMEM187 TMEM254 TMEM60 TMEM97 TSPO TTPA UNC93B1 VAMP4 ZFPL1 ZNF646
Entrez ID		81622	342900
HPRD ID		12191
Ensembl ID		ENSG00000110057	ENSG00000213921
Uniprot IDs		Q9H1C4	A8MZ59
PDB IDs		7C76 7CYN
Enriched GO Terms of Interacting Partners?		Membrane B Cell Receptor Complex Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Binding Endoplasmic Reticulum Membrane Steroid Biosynthetic Process Receptor Complex	Membrane
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