UNC93B1 and CCDC107

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UNC93B1	CCDC107
Description		unc-93B1 regulator of TLR signaling	coiled-coil domain containing 107
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagocytic Vesicle	Membrane
	Molecular Function	Protein Binding Toll-like Receptor Binding	Protein Binding
	Biological Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process T Cell Antigen Processing And Presentation Intracellular Protein Transport Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus
Pathways		Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE
Drugs
Diseases
GWAS		Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)	Severe insulin-deficient type 2 diabetes ( 34737425)
Interacting Genes		31 interacting genes: AQP6 BEST2 CCDC107 CD79A CFTR CLDN7 CLPTM1 CREB3L1 CYB5R3 EBP ERGIC3 FATE1 FFAR3 FKBP7 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35H1 SSMEM1 SYNDIG1 TM4SF18 TMEM237	9 interacting genes: ADGRE2 ADIPOQ APP GRM2 KPNA2 SLC35B1 TNF UBQLN4 UNC93B1
Entrez ID		81622	203260
HPRD ID		12191	14545
Ensembl ID		ENSG00000110057	ENSG00000159884
Uniprot IDs		Q9H1C4	Q8WV48
PDB IDs		7C76 7CYN
Enriched GO Terms of Interacting Partners?		Membrane B Cell Receptor Complex Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Binding Endoplasmic Reticulum Membrane Steroid Biosynthetic Process Receptor Complex	Positive Regulation Of Cytokine Production Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Astrocyte Projection Regulation Of Cytokine Production Positive Regulation Of Membrane Protein Ectodomain Proteolysis Endoplasmic Reticulum Positive Regulation Of CAMP/PKA Signal Transduction Toll-like Receptor 3 Signaling Pathway Astrocyte Activation Negative Regulation Of Blood Circulation Modulation Of Chemical Synaptic Transmission Regulation Of Interleukin-6 Production Regulation Of Amyloid-beta Clearance Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of DNA Metabolic Process Endolysosomal Toll-like Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Secretion By Cell Non-canonical NF-kappaB Signal Transduction Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Gene Expression Response To Stress Negative Regulation Of Synaptic Transmission Regulation Of Secretion Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of CAMP/PKA Signal Transduction Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Macrophage Activation Regulation Of ERK1 And ERK2 Cascade Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Localization
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