CDT1 and SMARCA5

Number of citations of the paper that reports this interaction (PubMedID 21937426)
74

Data Source:
BioGRID (pull down)

		CDT1	SMARCA5
Description		chromatin licensing and DNA replication factor 1	SNF2 related chromatin remodeling ATPase 5
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nuclear Body	Chromatin Condensed Chromosome Fibrillar Center Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin Nucleolus CHRAC NURF Complex ACF Complex ISWI-type Complex RSF Complex Site Of Double-strand Break Nuclear Replication Fork WICH Complex NoRC Complex CERF Complex B-WICH Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding	DNA Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nucleosome Binding Histone Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity Histone Octamer Slider Activity
	Biological Process	DNA Replication Checkpoint Signaling Mitotic Cell Cycle DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore DNA Replication Preinitiation Complex Assembly Response To Sorbitol Negative Regulation Of DNA-templated DNA Replication Positive Regulation Of DNA-templated DNA Replication	RDNA Heterochromatin Formation Regulation Of DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Transcription By RNA Polymerase I Heterochromatin Formation Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Antiviral Innate Immune Response Negative Regulation Of Mitotic Chromosome Condensation Cellular Response To Leukemia Inhibitory Factor
Pathways		Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state G1/S-Specific Transcription	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere
Drugs			Beta-D-Glucose 4-Deoxy-Alpha-D-Glucose
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 20139978 28017375 29403010) Mean corpuscular volume ( 29403010)	Appendicular lean mass ( 33097823) Height ( 31562340) Malaria ( 31844061)
Interacting Genes		27 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB	20 interacting genes: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B GSK3A H3-3A H3C1 H4C16 HDAC2 MAF POLE3 PTEN RAD21 RSF1 SATB1 USP7
Entrez ID		81620	8467
HPRD ID		06900	04538
Ensembl ID		ENSG00000167513	ENSG00000153147
Uniprot IDs		Q9H211	O60264
PDB IDs		2LE8 2WVR 6QCG 8RWV 8S0E 8S0F	6NE3 8V4Y 8V6V 8V7L 9E1L 9E1M 9E1N 9E1O 9E1P 9E1Q 9E1R 9E1U 9E1V 9E1W 9E1X
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Nucleoplasm Regulation Of DNA Replication DNA Damage Response Cellular Response To Stress DNA Replication DNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Macromolecule Metabolic Process Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Catabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cell Cycle G2/M Phase Transition DNA Replication Initiation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Positive Regulation Of Cell Cycle Post-translational Protein Modification Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Repair Regulation Of Primary Metabolic Process Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Organelle Organization Chromosome, Telomeric Region Response To Stress Mitotic G2/M Transition Checkpoint Cell Division Chromatin Binding Anaphase-promoting Complex	Chromatin Remodeling Chromatin Organization Protein-DNA Complex Assembly Nucleosome Assembly Nucleosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process CHRAC Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Pericentric Heterochromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Chromatin Negative Regulation Of Gene Expression, Epigenetic Macromolecule Metabolic Process Cellular Component Assembly Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Fungiform Papilla Formation Protein-containing Complex Assembly Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Chromosome Organization Negative Regulation Of Chromosome Condensation Regulation Of DNA Replication Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Hair Follicle Placode Formation Epsilon DNA Polymerase Complex Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Heterochromatin Formation Negative Regulation Of Gene Expression DNA Replication DNA-templated DNA Replication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process
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