CDT1 and DTL

Number of citations of the paper that reports this interaction (PubMedID 30623174)
83

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CDT1	DTL
Description		chromatin licensing and DNA replication factor 1	denticleless E3 ubiquitin protein ligase adapter
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nuclear Body	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	DNA Replication Checkpoint Signaling Mitotic Cell Cycle DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore DNA Replication Preinitiation Complex Assembly Response To Sorbitol Negative Regulation Of DNA-templated DNA Replication Positive Regulation Of DNA-templated DNA Replication	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To UV Positive Regulation Of Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Ubiquitination Translesion Synthesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle
Pathways		Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state G1/S-Specific Transcription	Recognition of DNA damage by PCNA-containing replication complex Neddylation
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 20139978 28017375 29403010) Mean corpuscular volume ( 29403010)	Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Height ( 20881960) Large artery stroke ( 28265093) Nickel levels ( 26025379) Plateletcrit ( 32888494)
Interacting Genes		27 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB	17 interacting genes: ATR CDK1 CDK2 CDKN1A CDT1 CHEK1 DDB1 KAT2A KMT5A PCNA POLD4 POLH TDG TOB1 TP53 UBE2D1 UBE2N
Entrez ID		81620	51514
HPRD ID		06900	17952
Ensembl ID		ENSG00000167513	ENSG00000143476
Uniprot IDs		Q9H211	B4E0E6 F5GZ90 Q9NZJ0
PDB IDs		2LE8 2WVR 6QCG 8RWV 8S0E 8S0F	6QC0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Nucleoplasm Regulation Of DNA Replication DNA Damage Response Cellular Response To Stress DNA Replication DNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Macromolecule Metabolic Process Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Catabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cell Cycle G2/M Phase Transition DNA Replication Initiation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Positive Regulation Of Cell Cycle Post-translational Protein Modification Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Repair Regulation Of Primary Metabolic Process Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Organelle Organization Chromosome, Telomeric Region Response To Stress Mitotic G2/M Transition Checkpoint Cell Division Chromatin Binding Anaphase-promoting Complex	Regulation Of DNA Metabolic Process DNA Metabolic Process DNA Repair DNA Damage Response DNA Replication Regulation Of DNA Replication Cellular Response To Stress Negative Regulation Of Cell Cycle Process Cellular Response To UV DNA Damage Checkpoint Signaling Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cellular Response To Light Stimulus Nucleoplasm Chromatin Organization Replicative Senescence Negative Regulation Of Cell Cycle Phase Transition Nucleic Acid Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Repair Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Positive Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Response To UV Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Chromosome, Telomeric Region Replication Fork Regulation Of Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleus Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Fibroblast Proliferation Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA Metabolic Process G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle
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