CDT1 and SKP2

Number of citations of the paper that reports this interaction (PMID 12840033)
66

Data Source:
HPRD (in vivo, in vitro)

		CDT1	SKP2
Gene Name		chromatin licensing and DNA replication factor 1	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Aggresome SCF Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion
Pathways		E2F mediated regulation of DNA replication Synthesis of DNA Activation of the pre-replicative complex DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition Activation of the pre-replicative complex S Phase Orc1 removal from chromatin Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex Mitotic G1-G1/S phases Switching of origins to a post-replicative state	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation G1 Phase S Phase Cyclin E associated events during G1/S transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 G1/S Transition Regulation of mitotic cell cycle Class I MHC mediated antigen processing & presentation Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases Adaptive Immune System
Drugs
Diseases
GWAS		mean corpuscular hemoglobin concentration ( 20139978)
Protein-Protein Interactions		29 interactors: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DDB1 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK1 MCM4 MCM6 MCM7 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB	54 interactors: AKT1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MYB MYBL2 MYC NLK ORC1 PFDN1 PIM1 PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1
Entrez ID		81620	6502
HPRD ID		06900	03256
Ensembl ID		ENSG00000167513	ENSG00000145604
Uniprot IDs		Q9H211	Q13309
PDB IDs		2LE8 2WVR	1FQV 1FS1 1FS2 1LDK 2ASS 2AST
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Cellular Response To Stress Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process DNA Replication Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Mitotic Cell Cycle Cellular Protein Catabolic Process Chromosome Organization Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Repair Nucleobase-containing Compound Metabolic Process Mitotic Nuclear Division Regulation Of Protein Ubiquitination G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Organelle Organization Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Negative Regulation Of Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cell Proliferation DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity DNA Metabolic Process Cellular Protein Modification Process
Tagcloud ?		assembled assembling cdc6 creates double generates head helicase heptamer hexamer hexamers hydrolysis interlocked intermediates juxtaposition license licensing loaded loaders mcm2 minichromosome misaligned multisubunit orc origins prereplication recruit replication replicative	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Difference) ?		assembled assembling cdc6 creates double generates head helicase heptamer hexamer hexamers hydrolysis interlocked intermediates juxtaposition license licensing loaded loaders mcm2 minichromosome misaligned multisubunit orc origins prereplication recruit replication replicative	antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1
Tagcloud (Intersection) ?