CDT1 and FBXO31

Number of citations of the paper that reports this interaction (PMID 24828503)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)

		CDT1	FBXO31
Gene Name		chromatin licensing and DNA replication factor 1	F-box protein 31
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	SCF Ubiquitin Ligase Complex Neuronal Cell Body
	Molecular Function	DNA Binding Protein Binding	Cyclin Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication	Cellular Response To DNA Damage Stimulus Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint
Pathways		E2F mediated regulation of DNA replication Synthesis of DNA Activation of the pre-replicative complex DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition Activation of the pre-replicative complex S Phase Orc1 removal from chromatin Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex Mitotic G1-G1/S phases Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		mean corpuscular hemoglobin concentration ( 20139978)	Major depressive disorder ( 22472876)
Protein-Protein Interactions		29 interactors: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DDB1 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK1 MCM4 MCM6 MCM7 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB	2 interactors: CCND1 CDT1
Entrez ID		81620	79791
HPRD ID		06900	10954
Ensembl ID		ENSG00000167513
Uniprot IDs		Q9H211	Q5XUX0
PDB IDs		2LE8 2WVR
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Cellular Response To Stress Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process DNA Replication Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Mitotic Cell Cycle Cellular Protein Catabolic Process Chromosome Organization Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Repair Nucleobase-containing Compound Metabolic Process Mitotic Nuclear Division Regulation Of Protein Ubiquitination G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Organelle Organization Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Negative Regulation Of Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Re-entry Into Mitotic Cell Cycle Regulation Of Cell Cycle Process Response To UV-A Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication Mitotic Cell Cycle Process DNA Replication Checkpoint Mitotic Cell Cycle Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Cycle Response To Magnesium Ion Response To Vitamin E Leydig Cell Differentiation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mammary Gland Epithelial Cell Proliferation Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Arrest Cell Cycle Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To X-ray Response To Corticosterone Response To Iron Ion Negative Regulation Of Epithelial Cell Differentiation Response To Mineralocorticoid Cell Cycle Mammary Gland Alveolus Development Mammary Gland Lobule Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Lactation Mitotic G1 DNA Damage Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Organ Regeneration Epithelial Cell Proliferation Endoplasmic Reticulum Unfolded Protein Response Canonical Wnt Signaling Pathway Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mammary Gland Epithelium Development Cellular Response To Unfolded Protein Mitotic DNA Integrity Checkpoint
Tagcloud ?		assembled assembling cdc6 creates double generates head helicase heptamer hexamer hexamers hydrolysis interlocked intermediates juxtaposition license licensing loaded loaders mcm2 minichromosome misaligned multisubunit orc origins prereplication recruit replication replicative
Tagcloud (Difference) ?		assembled assembling cdc6 creates double generates head helicase heptamer hexamer hexamers hydrolysis interlocked intermediates juxtaposition license licensing loaded loaders mcm2 minichromosome misaligned multisubunit orc origins prereplication recruit replication replicative
Tagcloud (Intersection) ?