CDT1 and CDC20

Number of citations of the paper that reports this interaction (PubMedID 18162579)
69

Data Source:
BioGRID (pull down)

		CDT1	CDC20
Description		chromatin licensing and DNA replication factor 1	cell division cycle 20
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nuclear Body	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Protein-containing Complex Mitotic Checkpoint Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding	Protein Binding Anaphase-promoting Complex Binding Histone Deacetylase Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	DNA Replication Checkpoint Signaling Mitotic Cell Cycle DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore DNA Replication Preinitiation Complex Assembly Response To Sorbitol Negative Regulation Of DNA-templated DNA Replication Positive Regulation Of DNA-templated DNA Replication	G2/M Transition Of Mitotic Cell Cycle Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Nervous System Development Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Protein Deubiquitination Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiotic Nuclear Division Metaphase/anaphase Transition Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Dendrite Development Cell Division Regulation Of Meiotic Cell Cycle Positive Regulation Of Synapse Maturation Mitotic Spindle Assembly Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Metaphase/anaphase Transition Of Meiosis I
Pathways		Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state G1/S-Specific Transcription	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of Cyclin B SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of Emi1 APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Ub-specific processing proteases Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 20139978 28017375 29403010) Mean corpuscular volume ( 29403010)	Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		27 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB	52 interacting genes: ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CDC16 CDC27 CDC6 CDK1 CDR2 CDT1 DCPS DTYMK EGLN3 FADD FBXO5 GMNN H2BC3 H3C1 HDAC1 HDAC2 HSF1 HSF2 KIF18A MAD2L1 MAD2L2 MCL1 MKI67 NEK2 OTUD7B PIM1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TBK1 TCP1 TGFBR1 TK1 TP63 TRIP13 UBC UBE2C UBE2S UBR5
Entrez ID		81620	991
HPRD ID		06900	04686
Ensembl ID		ENSG00000167513	ENSG00000117399
Uniprot IDs		Q9H211	Q12834
PDB IDs		2LE8 2WVR 6QCG 8RWV 8S0E 8S0F	4GGA 4GGC 4GGD 4N14 5G04 5KHR 5KHU 5LCW 6F0X 6Q6G 6Q6H 9I68 9I69 9I6A
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Nucleoplasm Regulation Of DNA Replication DNA Damage Response Cellular Response To Stress DNA Replication DNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Macromolecule Metabolic Process Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Catabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cell Cycle G2/M Phase Transition DNA Replication Initiation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Positive Regulation Of Cell Cycle Post-translational Protein Modification Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Repair Regulation Of Primary Metabolic Process Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Organelle Organization Chromosome, Telomeric Region Response To Stress Mitotic G2/M Transition Checkpoint Cell Division Chromatin Binding Anaphase-promoting Complex	Cell Division Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex Regulation Of Chromosome Segregation Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Nuclear Division Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process Protein Branched Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Regulation Of Reproductive Process Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Nucleus Protein Modification Process Positive Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Protein K48-linked Ubiquitination Cytosol Cell Cycle Phase Transition Spindle Negative Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Nuclear Division Post-translational Protein Modification Positive Regulation Of Cell Cycle Phase Transition Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic Spindle Negative Regulation Of Cell Cycle Process Macromolecule Metabolic Process Regulation Of Cellular Component Organization Protein Polyubiquitination Modification-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition
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