CALU and APCS

Number of citations: 0 (PubMedID 10631319)
Data Source: HPRD (in vitro)

		CALU	APCS
Name		calumenin	amyloid P component, serum
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Lumen Melanosome	Extracellular Region Extracellular Space Nucleus Extracellular Exosome Blood Microparticle
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Identical Protein Binding Virion Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	None	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Host-mediated Suppression Of Symbiont Invasion Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Amyloid fiber formation
Drugs		None	Zinc Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper Zinc acetate
GWAS		Atrial fibrillation ( 30061737 ) Intelligence (MTAG) ( 29326435 ) Moderate to vigorous physical activity levels ( 29899525 ) Primary tooth development (number of teeth) ( 23704328 ) Primary tooth development (time to first tooth eruption) ( 23704328 ) Reading disability or specific language impairment (pleiotropy) ( 25065397 ) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397 ) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552 )	Blood protein levels ( 30072576 ) C-reactive protein ( 22939635 ) Neonatal white matter microstructure ( 33009551 )
Interacting Genes		11 interacting genes: APCS CEBPA CSNK2A1 CTNNAL1 MFHAS1 PRMT5 SNCA UBE2I UBQLN1 UMPS ZPBP	18 interacting genes: ALX1 C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG
Entrez ID		813	325
HPRD ID		04569	00101
Ensembl ID		ENSG00000128595	ENSG00000132703
Uniprot IDs		B3KQF5 O43852 Q6IAW5	P02743 V9HWP0
PDB IDs		Not available	1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
GO Terms Enriched among Interactors		Regulation Of Macrophage Activation Identical Protein Binding Aggrephagy Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Protein Catabolic Process Acute-phase Response Negative Regulation Of Immune System Process Cellular Component Assembly Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission SUMO Conjugating Enzyme Activity Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Store-operated Calcium Channel Activity Acute Inflammatory Response Protein-containing Complex Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Response To Vitamin B2 C/EBP Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Peptidyl-arginine N-methylation Regulation Of Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinase Binding CHOP-C/EBP Complex Regulation Of Proteolysis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Autophagy Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy RING-like Zinc Finger Domain Binding 'de Novo' UMP Biosynthetic Process Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway	IgG Binding IgG Receptor Activity Acute Inflammatory Response Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Immune Effector Process Leukocyte Mediated Immunity Leukocyte Mediated Cytotoxicity Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway Low-affinity IgG Receptor Activity Cell Killing Defense Response Response To Other Organism Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Adaptive Immune Response Extracellular Region Immune Response Inflammatory Response Retinal Blood Vessel Morphogenesis Response To External Biotic Stimulus Regulation Of Immune Response Innate Immune Response Immune System Process Positive Regulation Of Immune System Process Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Lymphocyte Mediated Immunity Retina Vasculature Morphogenesis In Camera-type Eye Immune Response-regulating Signaling Pathway Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Basement Membrane Regulation Of Mononuclear Cell Proliferation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Acute Inflammatory Response To Antigenic Stimulus Renal Tubule Morphogenesis Blood Vessel Morphogenesis Regulation Of Leukocyte Proliferation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Leukocyte Activation Extracellular Matrix Structural Constituent