CALU and UBQLN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CALU	UBQLN1
Description		calumenin	ubiquilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Lumen Melanosome	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Aggresome Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding
	Biological Process		Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Autophagy Macroautophagy Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Aggrephagy ERAD Pathway Negative Regulation Of Transport Cellular Response To Hypoxia Autophagosome Maturation Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ERAD Pathway
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Intelligence (MTAG) ( 29326435) Moderate to vigorous physical activity levels ( 29899525) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)	Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: APCS CEBPA CSNK2A1 CTNNAL1 MFHAS1 PRMT5 SNCA UBE2I UBQLN1 UMPS ZPBP	233 interacting genes: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 ANOS1 APOC2 APOC4 APP ASCL1 ATXN3 BAG6 BPIFA1 C1QA C1QTNF2 C1QTNF4 CALU CARINH CCL3 CCL7 CD47 CD99 CD99L2 CDIP1 CDSN CEBPA CHGB CHRNA3 CHRNA4 CHRNB4 CLCN2 COL10A1 COL1A2 COL9A2 COLGALT2 COMTD1 COPS4 CSN3 CSTF2 CSTF2T CTAG1A CTAG1B CTAG2 CYB5R1 DAZAP2 DEFA6 DEFB115 DESI1 DEXI DMKN DNAJB2 DOLK ECM1 EFEMP2 ENTREP1 EP300 EPS15 ERP27 ERP29 ETNK1 F8 FAM163B FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FOLR3 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GAL GHRL GIT2 GKAP1 GPR162 GPX3 GRM2 GUCA2A GUCA2B GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IER3IP1 IGFBP6 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 JPH4 JSRP1 KLHL42 LAIR2 LAMB1 LCN2 LHX4 LITAF LNPEP MANBAL MAP3K1 MCM7 MDK MESD MICOS10-NBL1 MIEF1 MIEF2 MLLT6 MTNR1A MTOR MYDGF NAXD NBL1 NDE1 NDOR1 NEDD8 NGLY1 NLGN3 NME3 NPPA NPY NT5C3A NUP58 NXF1 OST4 P4HB PARVA PBXIP1 PCDH18 PCDHA4 PIAS2 PIK3IP1 PLAAT1 PLAAT2 PLAAT3 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PRR4 PSEN1 PSEN2 PSMD4 PSORS1C2 PTN RAI2 RARA RASSF5 RIC8A RNF144B RNF208 RNF4 RPN1 RPS27A RSRC2 RTL8A RTL8B RTL8C SCG2 SCG5 SCMH1 SERPINE1 SERPINI2 SEZ6L SIL1 SLC16A3 SLC29A2 SLPI SMAD9 SMIM19 SMIM2 SMR3B SMURF1 SOD3 SPAG8 SPARC SRGN STAM2 STMN3 SUSD4 SYNJ2BP TARDBP TFF1 TICAM1 TLR4 TMCO6 TMEM258 TMEM37 TMEM67 TMUB2 TNFAIP3 TNFRSF1A TNFRSF1B TREX1 TRIM23 TRIM32 TXNDC12 UBA52 UBB UBC UBE2I UBE2V1 UBQLN4 UBXN1 UBXN4 UBXN7 VWC2 WBP2 WFDC12 WWP2 XPO4 ZBTB8B ZFAND2B ZG16 ZG16B ZMYM5 ZNF343
Entrez ID		813	29979
HPRD ID		04569	05440
Ensembl ID		ENSG00000128595	ENSG00000135018
Uniprot IDs		B3KQF5 O43852 Q6IAW5	Q9UMX0
PDB IDs			2JY5 2JY6 2KLC
Enriched GO Terms of Interacting Partners?		Regulation Of Macrophage Activation Identical Protein Binding Aggrephagy Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Protein Catabolic Process Acute-phase Response Negative Regulation Of Immune System Process Cellular Component Assembly Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission SUMO Conjugating Enzyme Activity Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Store-operated Calcium Channel Activity Acute Inflammatory Response Protein-containing Complex Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Response To Vitamin B2 C/EBP Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Peptidyl-arginine N-methylation Regulation Of Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinase Binding CHOP-C/EBP Complex Regulation Of Proteolysis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Autophagy Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy RING-like Zinc Finger Domain Binding 'de Novo' UMP Biosynthetic Process Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway	Extracellular Region Extracellular Ligand-gated Monoatomic Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Protein Binding Extracellular Space GABA-gated Chloride Ion Channel Activity Regulation Of Postsynaptic Membrane Potential Gamma-aminobutyric Acid Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Endoplasmic Reticulum Lumen Chloride Channel Complex Chloride Channel Activity Inhibitory Synapse Assembly Postsynaptic Membrane Positive Regulation Of Glial Cell Differentiation Polyubiquitin Modification-dependent Protein Binding Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Tag Activity Regulation Of Membrane Potential Transmembrane Signaling Receptor Activity Cell-cell Signaling Endoplasmic Reticulum Behavioral Response To Nicotine Regulation Of Tumor Necrosis Factor Production Regulation Of Mononuclear Cell Migration Regulation Of Proteolysis Synaptic Signaling Signaling Chemical Synaptic Transmission Positive Regulation Of Oligodendrocyte Differentiation Chloride Transmembrane Transport Benzodiazepine Receptor Activity Ubiquitin Binding GABA-ergic Synapse Proteolysis Monoatomic Anion Transmembrane Transport Macromolecule Catabolic Process Cell Communication Regulation Of Oligodendrocyte Differentiation Regulation Of Leukocyte Migration Chloride Transport Trans-synaptic Signaling Monoatomic Ion Channel Activity Oligosaccharyltransferase Complex Positive Regulation Of Nervous System Development Monoatomic Anion Transport
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