CALU and ZPBP

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CALU	ZPBP
Name		calumenin	zona pellucida binding protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Lumen Melanosome	Acrosomal Vesicle Acrosomal Membrane Zona Pellucida Receptor Complex Extracellular Region Nucleus Membrane Cytoplasmic Vesicle
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	None
	Biological Process	None	Acrosome Assembly Binding Of Sperm To Zona Pellucida
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	None
GWAS		Atrial fibrillation ( 30061737 ) Intelligence (MTAG) ( 29326435 ) Moderate to vigorous physical activity levels ( 29899525 ) Primary tooth development (number of teeth) ( 23704328 ) Primary tooth development (time to first tooth eruption) ( 23704328 ) Reading disability or specific language impairment (pleiotropy) ( 25065397 ) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397 ) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552 )	Body mass index ( 26426971 ) Body mass index (age <50) ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Crohn's disease ( 21102463 28067908 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 23128233 28067908 ) Metabolite levels ( 23823483 ) Total ventricular volume (Alzheimer's disease interaction) ( 21116278 )
Interacting Genes		11 interacting genes: APCS CEBPA CSNK2A1 CTNNAL1 MFHAS1 PRMT5 SNCA UBE2I UBQLN1 UMPS ZPBP	3 interacting genes: CALU ERRFI1 ZP2
Entrez ID		813	11055
HPRD ID		04569	18364
Ensembl ID		ENSG00000128595	ENSG00000042813
Uniprot IDs		B3KQF5 O43852 Q6IAW5	Q9BS86
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Macrophage Activation Identical Protein Binding Aggrephagy Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Protein Catabolic Process Acute-phase Response Negative Regulation Of Immune System Process Cellular Component Assembly Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission SUMO Conjugating Enzyme Activity Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Store-operated Calcium Channel Activity Acute Inflammatory Response Protein-containing Complex Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Response To Vitamin B2 C/EBP Complex Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Peptidyl-arginine N-methylation Regulation Of Immune System Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinase Binding CHOP-C/EBP Complex Regulation Of Proteolysis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Autophagy Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy RING-like Zinc Finger Domain Binding 'de Novo' UMP Biosynthetic Process Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway	Sarcoplasmic Reticulum Lumen Structural Constituent Of Egg Coat Regulation Of Acrosome Reaction Prevention Of Polyspermy Acrosin Binding Regulation Of Fertilization Egg Coat Negative Regulation Of Protein Autophosphorylation Chondrocyte Proliferation Negative Regulation Of Collagen Biosynthetic Process Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Oviduct Epithelium Development Lung Vasculature Development Limb Joint Morphogenesis Uterine Epithelium Development Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Lung Epithelium Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Response To 1-oleoyl-sn-glycerol 3-phosphate Cellular Hyperosmotic Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Response To Platelet-derived Growth Factor Stimulus Uterus Development Regulation Of Protein Tyrosine Kinase Activity Bile Acid Biosynthetic Process Response To Platelet-derived Growth Factor Hyperosmotic Response Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Dexamethasone Stimulus Binding Of Sperm To Zona Pellucida Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of ERBB Signaling Pathway Bile Acid Metabolic Process Response To Progesterone Regulation Of Signaling Receptor Activity Sperm-egg Recognition Regulation Of Collagen Biosynthetic Process Negative Regulation Of Interleukin-1 Production Regulation Of Keratinocyte Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Multivesicular Body Embryo Implantation