PHF19 and SUV39H2

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PHF19	SUV39H2
Gene Name		PHD finger protein 19	suppressor of variegation 3-9 homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm ESC/E(Z) Complex	Chromosome, Centromeric Region Chromatin Nucleoplasm Nuclear Heterochromatin
	Molecular Function	Protein Binding Zinc Ion Binding Methylated Histone Binding	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K9 Specific)
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Chromatin Modification Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K27 Methylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Assembly Or Disassembly Chromatin Remodeling Transcription, DNA-templated Male Meiosis Cell Differentiation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways		Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: KDM1A SUV39H1 SUV39H2	39 interactors: AKAP9 APPL2 BLZF1 C8orf74 CBX5 CBX7 CCDC151 CCDC37 CDCA4 CEP70 CGGBP1 EWSR1 FAM20C GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MCM3AP MRFAP1 MTF2 MYL12A NME4 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57
Entrez ID		26147	79723
HPRD ID		17846	07580
Ensembl ID		ENSG00000119403	ENSG00000152455
Uniprot IDs		B3KV88 F5H8K3 Q5T6S3	Q9H5I1
PDB IDs		2E5Q 4BD3	2R3A
Enriched GO Terms of Interacting Partners?		Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Peptidyl-lysine Dimethylation Negative Regulation Of Circadian Rhythm Histone H3-K9 Methylation Peptidyl-lysine Trimethylation Histone Modification Histone H3-K9 Modification Chromatin Modification Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone Lysine Methylation Regulation Of Circadian Rhythm Peptidyl-lysine Methylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Histone Methylation Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primitive Erythrocyte Differentiation Protein Methylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Peptidyl-lysine Modification Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Methylation Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Chromatin Silencing At RDNA Granulocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Histone Methylation Organelle Organization RNA Metabolic Process Cellular Protein Modification Process	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Histone H3-K27 Methylation Regulation Of RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Osteoblast Differentiation Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Golgi To Plasma Membrane Transport Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Positive Regulation Of DNA Metabolic Process Osteoclast Maturation Regulation Of Histone Methylation Regulation Of Ossification Protein Targeting Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process Establishment Of Protein Localization To Membrane Positive Regulation Of DNA Replication Positive Regulation Of Histone Modification Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Osteoblast Differentiation Myeloid Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition
Tagcloud ?		aberrant astrocytoma atlas cbx6 cbx7 cbx8 diminished discovered epigenetics evolution ezh1 ezh2 gbm gbms glioblastoma interrogating malignancy multiforme overexpressed pcg phc2 polycomb progressively qrt rybp striking systematically tcga widespread	a7 circular dichroism dim g12 g13 g9a h3k9 h3k9me0 h3k9me1 h3k9me2 h3k9me3 introduce introduces k14 labrador n324k pkmts prefers processive r8 readout recognizes renders retrievers s10 t11 t6
Tagcloud (Difference) ?		aberrant astrocytoma atlas cbx6 cbx7 cbx8 diminished discovered epigenetics evolution ezh1 ezh2 gbm gbms glioblastoma interrogating malignancy multiforme overexpressed pcg phc2 polycomb progressively qrt rybp striking systematically tcga widespread	a7 circular dichroism dim g12 g13 g9a h3k9 h3k9me0 h3k9me1 h3k9me2 h3k9me3 introduce introduces k14 labrador n324k pkmts prefers processive r8 readout recognizes renders retrievers s10 t11 t6
Tagcloud (Intersection) ?