LIN7A and PALS1

Number of citations of the paper that reports this interaction (PubMedID 10753959)
0

Data Source:
HPRD (in vitro)

		LIN7A	PALS1
Description		lin-7 cell polarity scaffold A	protein associated with LIN7 1, MAGUK p55 family member
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Adherens Junction Bicellular Tight Junction Endomembrane System Membrane Apical Plasma Membrane Axon Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Myelin Sheath Adaxonal Region Cell Projection Perikaryon Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity L27 Domain Binding	Nucleotide Binding Protein Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly	Morphogenesis Of An Epithelial Sheet Plasma Membrane Organization Intracellular Protein Localization Gene Expression Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Development Cerebral Cortex Development Peripheral Nervous System Myelin Maintenance Myelin Assembly Protein Localization To Myelin Sheath Abaxonal Region Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Generation Of Neurons Protein Localization To Plasma Membrane
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Tight junction interactions SARS-CoV-1 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases
GWAS		Age-related cataracts (age at onset) ( 25352737) Dental caries ( 23259602)
Interacting Genes		25 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK CHRD DLG2 DLG3 DLG4 DNAJC5 ECM1 FAM9B GOLGA2 GRIN2B KCNJ12 MDFI MPP2 MPP3 MPP7 NOTCH2NLA PALS1 PALS2 SLC6A12 VANGL2 ZYX	14 interacting genes: ARF6 CRB3 DLGAP4 FTCD GPRASP3 LIN7A MPP4 NUMB PARD6B PATJ SNTG2 SOCS4 SRGAP2B TRAF2
Entrez ID		8825	64398
HPRD ID		04542	09508
Ensembl ID		ENSG00000111052	ENSG00000072415
Uniprot IDs		O14910	Q8N3R9
PDB IDs			1Y76 3UIT 4UU5 4UU6 4WSI 7M4R 7NTJ 7NTK 7QCS
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Adherens Junction Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Excitatory Postsynaptic Potential Protein Localization To Cell Junction Plasma Membrane Regulation Of Synaptic Plasticity Postsynaptic Density Membrane Modulation Of Excitatory Postsynaptic Potential Basolateral Plasma Membrane Postsynaptic Density Protein Localization To Synapse Synaptic Membrane Dendritic Spine Modulation Of Chemical Synaptic Transmission Neuromuscular Junction PDZ Domain Binding Cellular Component Assembly Neuron Projection Protein Tetramerization Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Binding Presynapse Organelle Cell Adhesion Regulation Of Nervous System Process Dendritic Shaft Protein Complex Oligomerization Ligand-gated Ion Channel Signaling Pathway NMDA Selective Glutamate Receptor Signaling Pathway Cell Projection Receptor Localization To Synapse Receptor Clustering Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Regulation Of Synapse Organization GMP Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Neuronal Synaptic Plasticity Chemical Synaptic Transmission Intracellular Protein Localization Trans-synaptic Signaling GDP Metabolic Process Synaptic Signaling Juxtaparanode Region Of Axon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Acetylcholine Receptor Binding	Apical Part Of Cell Regulation Of Cell Junction Assembly Regulation Of Synapse Organization Bicellular Tight Junction Regulation Of Synapse Assembly Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Thioesterase Binding Cell Junction Organization Regulation Of Cellular Component Organization Apical Junction Complex Anchoring Junction Cell Cortex Cell-cell Junction Organization Tight Junction Cell Division Cell Junction Positive Regulation Of Cellular Component Biogenesis Erythrocyte Apoptotic Process TORC2 Complex Disassembly Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Extracellular Exosome Regulation Of Dendritic Spine Development Glutamatergic Synapse Plasma Membrane TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide Signaling Adaptor Activity Protein Localization To Cleavage Furrow Neuroblast Division In Subventricular Zone L27 Domain Binding Subapical Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?