LIN7A and GRIN2B

Number of citations of the paper that reports this interaction (PMID 10341223)
32

Data Source:
HPRD (in vitro)

		LIN7A	GRIN2B
Gene Name		lin-7 homolog A (C. elegans)	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cell-cell Junction Tight Junction Postsynaptic Density Basolateral Plasma Membrane Neuron Projection Synapse Postsynaptic Membrane Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex	Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Protein Binding PDZ Domain Binding L27 Domain Binding	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding Glycine Binding
	Biological Process	Protein Complex Assembly Exocytosis Neurotransmitter Secretion Asymmetric Protein Localization Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Vesicle Transport Inner Ear Development Protein Localization To Basolateral Plasma Membrane	Behavioral Fear Response In Utero Embryonic Development Startle Response Suckling Behavior Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Axon Guidance Sensory Organ Development Learning Or Memory Learning Memory Regulation Of Protein Kinase A Signaling Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Behavioral Response To Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport
Pathways			EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs			L-Glutamic Acid Meperidine Haloperidol Felbamate Memantine Tenocyclidine
Diseases
GWAS		Dental caries ( 23259602)	Aging (time to event) ( 21782286) Brain structure (temporal lobe volume) ( 20197096) Cognitive performance ( 19734545) Immune reponse to smallpox (secreted IL-2) ( 22610502) Major depressive disorder ( 23377640) Ovarian reserve ( 22116950) Total ventricular volume ( 21116278)
Protein-Protein Interactions		19 interactors: ABCA1 APP BAI1 BAIAP2 CASK DLG2 DLG3 DLG4 FAM9B GOLGA2 GRIN2B KCNJ12 MPP2 MPP3 MPP5 MPP6 NOTCH2NL SLC6A12 ZYX	40 interactors: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 DLG1 DLG2 DLG3 DLG4 EPHB2 ERBB2IP EXOC4 EXOC7 FYN GNB2L1 GRIN1 GRIN3A IL16 INADL LIN7A LIN7B MAGI3 MIB2 PARK2 PIK3CA PLCG1 PRKCA PRKCB PRKCG PTPN11 SPTAN1 SRC SYNGAP1 TANC1
Entrez ID		8825	2904
HPRD ID		04542	00697
Ensembl ID		ENSG00000111052
Uniprot IDs		O14910	Q13224
PDB IDs			1S11 1S2S 2IPV
Enriched GO Terms of Interacting Partners?		Nucleotide Phosphorylation Receptor Localization To Synapse Protein Localization To Synapse Axonogenesis Signaling Cell-cell Signaling Cell Communication Nucleotide Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Receptor Clustering Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Cellular Component Assembly Neuron Development Signal Transduction Organophosphate Metabolic Process Secretion Cell Morphogenesis Cellular Response To Stimulus Neuron Differentiation Neurogenesis Neuromuscular Process Nervous System Development Suckling Behavior Cell Projection Organization Protein Localization To Membrane Dendrite Development Multicellular Organismal Development Small Molecule Metabolic Process Learning Axon Guidance Anatomical Structure Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Cell Development Regulation Of Synaptic Plasticity Phosphorylation System Development Cell Differentiation Secretion By Cell Ionotropic Glutamate Receptor Signaling Pathway Developmental Process Generation Of Neurons Protein Localization To Myelin Sheath Abaxonal Region	Synaptic Transmission Cell-cell Signaling Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemotaxis Signaling Cell Communication Axon Guidance Cell Projection Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Projection Development Receptor Localization To Synapse Regulation Of Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Movement Of Cell Or Subcellular Component Axonogenesis Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Learning Response To Stimulus Neuron Projection Morphogenesis Nervous System Development Locomotion Fibroblast Growth Factor Receptor Signaling Pathway Learning Or Memory Response To External Stimulus Ephrin Receptor Signaling Pathway Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Synapse Protein Localization Receptor Clustering Cognition Blood Coagulation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Body Fluid Levels Cellular Response To Stimulus Hemostasis Platelet Activation
Tagcloud ?		adherens associates cadherin carboxyl changing compartment deleted dimer dimerizes dlg1 guanylate homology insoluble junctions l27 lin7c localizes maguk members mpp7 pdz redistributes requiring stabilizes stabilizing stardust tripartite uncharacterized	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		adherens associates cadherin carboxyl changing compartment deleted dimer dimerizes dlg1 guanylate homology insoluble junctions l27 lin7c localizes maguk members mpp7 pdz redistributes requiring stabilizes stabilizing stardust tripartite uncharacterized	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?