LIN7A and SLC6A12

Number of citations of the paper that reports this interaction (PMID 10228153)
20

Data Source:
HPRD (in vitro, in vivo)

		LIN7A	SLC6A12
Gene Name		lin-7 homolog A (C. elegans)	solute carrier family 6 (neurotransmitter transporter), member 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cell-cell Junction Tight Junction Postsynaptic Density Basolateral Plasma Membrane Neuron Projection Synapse Postsynaptic Membrane Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding PDZ Domain Binding L27 Domain Binding	Neurotransmitter:sodium Symporter Activity Gamma-aminobutyric Acid:sodium Symporter Activity
	Biological Process	Protein Complex Assembly Exocytosis Neurotransmitter Secretion Asymmetric Protein Localization Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Vesicle Transport Inner Ear Development Protein Localization To Basolateral Plasma Membrane	Transport Ion Transport Amino Acid Transport Synaptic Transmission Neurotransmitter Secretion Cellular Water Homeostasis Response To Organic Substance Gamma-aminobutyric Acid Transport Transmembrane Transport Cellular Hyperosmotic Response
Pathways			Na+/Cl- dependent neurotransmitter transporters Transport of inorganic cations/anions and amino acids/oligopeptides Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds GABA synthesis, release, reuptake and degradation SLC-mediated transmembrane transport Metabolism of amino acids and derivatives Reuptake of GABA Neurotransmitter Release Cycle Amino acid transport across the plasma membrane Creatine metabolism Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Dental caries ( 23259602)	Chronic kidney disease ( 20383146) Metabolite levels ( 23378610)
Protein-Protein Interactions		19 interactors: ABCA1 APP BAI1 BAIAP2 CASK DLG2 DLG3 DLG4 FAM9B GOLGA2 GRIN2B KCNJ12 MPP2 MPP3 MPP5 MPP6 NOTCH2NL SLC6A12 ZYX	3 interactors: ERBB2IP LIN7A REL
Entrez ID		8825	6539
HPRD ID		04542	04358
Ensembl ID		ENSG00000111052	ENSG00000111181
Uniprot IDs		O14910	P48065
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide Phosphorylation Receptor Localization To Synapse Protein Localization To Synapse Axonogenesis Signaling Cell-cell Signaling Cell Communication Nucleotide Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Receptor Clustering Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Cellular Component Assembly Neuron Development Signal Transduction Organophosphate Metabolic Process Secretion Cell Morphogenesis Cellular Response To Stimulus Neuron Differentiation Neurogenesis Neuromuscular Process Nervous System Development Suckling Behavior Cell Projection Organization Protein Localization To Membrane Dendrite Development Multicellular Organismal Development Small Molecule Metabolic Process Learning Axon Guidance Anatomical Structure Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Cell Development Regulation Of Synaptic Plasticity Phosphorylation System Development Cell Differentiation Secretion By Cell Ionotropic Glutamate Receptor Signaling Pathway Developmental Process Generation Of Neurons Protein Localization To Myelin Sheath Abaxonal Region	Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Cell Polarity Basal Protein Localization Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Interleukin-12 Biosynthetic Process Maintenance Of Cell Polarity Regulation Of Interleukin-12 Biosynthetic Process
Tagcloud ?		adherens associates cadherin carboxyl changing compartment deleted dimer dimerizes dlg1 guanylate homology insoluble junctions l27 lin7c localizes maguk members mpp7 pdz redistributes requiring stabilizes stabilizing stardust tripartite uncharacterized
Tagcloud (Difference) ?		adherens associates cadherin carboxyl changing compartment deleted dimer dimerizes dlg1 guanylate homology insoluble junctions l27 lin7c localizes maguk members mpp7 pdz redistributes requiring stabilizes stabilizing stardust tripartite uncharacterized
Tagcloud (Intersection) ?