TET1 and MBD3

Number of citations of the paper that reports this interaction (PMID 22196727)
88

Data Source:
BioGRID (pull down)

		TET1	MBD3
Gene Name		tet methylcytosine dioxygenase 1	methyl-CpG binding domain protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein Complex
	Molecular Function	Iron Ion Binding Zinc Ion Binding Structure-specific DNA Binding Methylcytosine Dioxygenase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Inner Cell Mass Cell Differentiation Transcription, DNA-templated Protein O-linked Glycosylation Gene Expression Chromatin Modification Stem Cell Maintenance Oxidative DNA Demethylation Regulation Of Gene Expression, Epigenetic Regulation Of DNA Methylation Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Demethylation Negative Regulation Of Methylation-dependent Chromatin Silencing	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Organization Methylation-dependent Chromatin Silencing Transcription, DNA-templated Tissue Development Histone Acetylation ATP-dependent Chromatin Remodeling
Pathways		TET1,2,3 and TDG demethylate DNA Epigenetic regulation of gene expression	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: MBD3	28 interactors: AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 HDAC1 HIST3H3 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA1 MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZNF277
Entrez ID		80312	53615
HPRD ID		09694	04653
Ensembl ID		ENSG00000138336	ENSG00000071655
Uniprot IDs		Q8NFU7	O95983
PDB IDs
Enriched GO Terms of Interacting Partners?		Methylation-dependent Chromatin Silencing Chromatin Silencing ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Gene Silencing Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation	ATP-dependent Chromatin Remodeling Regulation Of Gene Expression, Epigenetic Chromatin Organization Transcription, DNA-templated Chromosome Organization Chromatin Modification RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Remodeling RNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Negative Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process DNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA Modification Histone Modification Negative Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Interaction With Symbiont Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Histone H3-K4 Demethylation Chromatin Assembly Or Disassembly Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Binding
Tagcloud ?		analytical analyzing briefly chapter clearly concepts converting details discovery emerging epigenetic evidences growing heterozygous hydroxymethylcytosine invaluable knockout mentioned methylation microrna modification noncoding opioid opioids others played reductions rnas subheading	accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie
Tagcloud (Difference) ?		analytical analyzing briefly chapter clearly concepts converting details discovery emerging epigenetic evidences growing heterozygous hydroxymethylcytosine invaluable knockout mentioned methylation microrna modification noncoding opioid opioids others played reductions rnas subheading	accompanying amounts blastocysts counterparts dynamic earliest ega embryos fertilization gradual gradually h3k27 h3k27ac hatched hdac1 hdac2 ivf lineage mark morula onwards pa parthenogenetic porcine pronuclear reprogramming scnt specification underlie
Tagcloud (Intersection) ?