PMEPA1

Description		prostate transmembrane protein, androgen induced 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane
	Molecular Function	Protein Binding WW Domain Binding R-SMAD Binding Protein Sequestering Activity
	Biological Process	Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Negative Regulation Of SMAD Protein Signal Transduction
Pathways		Downregulation of TGF-beta receptor signaling
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Response to fenofibrate (adiponectin levels) ( 23149075) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event) ( 33455090) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		11 interacting genes: DCTN5 DCTN6 EPN2 HGS NEDD4 OTUB2 SGTA STAM UBASH3A UBQLN2 UBQLN4
Entrez ID		56937
HPRD ID		09415
Ensembl ID		ENSG00000124225
Uniprot IDs		Q5JY37 Q969W9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Ubiquitin Binding Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway ESCRT-0 Complex Regulation Of Protein Catabolic Process Establishment Of Protein Localization To Vacuole Dynactin Complex Protein Localization To Vacuole Autophagy Establishment Of Protein Localization To Organelle Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of ERAD Pathway Regulation Of Exosomal Secretion Cytosol Regulation Of ERAD Pathway Ubiquitin-like Protein Ligase Binding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Protein Targeting To Lysosome Multivesicular Body Assembly Multivesicular Body Organization Regulation Of Macroautophagy Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Late Endosome To Vacuole Transport Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Protein Targeting To Vacuole Proteolysis Catabolic Process Protein Localization To Lysosome Proteolysis Involved In Protein Catabolic Process Formation Of Structure Involved In A Symbiotic Process Cytoplasm Receptor Internalization Channel Inhibitor Activity Regulation Of Cellular Response To Growth Factor Stimulus TRC Complex Positive Regulation Of Exocytosis Endosome Organization Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Regulation Of Autophagy
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