TIMM8A and STAM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIMM8A	STAM2
Description		translocase of inner mitochondrial membrane 8A	signal transducing adaptor molecule 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Intermembrane Space Chaperone Complex	Nucleoplasm Cytoplasm Endosome Cytosol Membrane Endocytic Vesicle Early Endosome Membrane ESCRT-0 Complex
	Molecular Function	Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Protein Targeting To Mitochondrion Nervous System Development Protein Transport Protein Insertion Into Mitochondrial Inner Membrane	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission
Pathways		Mitochondrial protein import	EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases		Mohr-Tranebjaerg syndrome
GWAS			Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)
Interacting Genes		8 interacting genes: ARID3A C1QTNF2 CAVIN3 KRT15 OIP5 STAM STAM2 TIMM13	37 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 CDC7 DAZAP2 EGFR ENTREP1 EPS15 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN1 UBQLN4 USP8 VPS37C XRN1 ZC3H10
Entrez ID		1678	10254
HPRD ID		02287	05876
Ensembl ID		ENSG00000126953	ENSG00000115145
Uniprot IDs		A0A2R8YDA8 O60220	O75886
PDB IDs			1X2Q 1X5B 2L0T 5CRV 5IXF
Enriched GO Terms of Interacting Partners?		ESCRT-0 Complex Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Organelle Organization Establishment Of Protein Localization To Organelle Endosome Organization Protein Localization To Vacuole Ubiquitin Binding Phosphatidylinositol Binding Pericentric Heterochromatin Organization CENP-A Recruiting Complex Negative Regulation Of Fermentation	Endosome Growth Hormone Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Early Endosome Proteolysis Cell Surface Receptor Signaling Pathway Via STAT Extrinsic Component Of Plasma Membrane Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Protein Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein K48-linked Ubiquitination Protein-containing Complex Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Signal Transduction Early Endosome Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Type II Interferon-mediated Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Cell Communication Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Interleukin-12 Receptor Complex Ubiquitin-protein Transferase Activity Protein Autoubiquitination Receptor Internalization Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Interleukin-23 Receptor Complex Cytosol Protein Polyubiquitination Endosome Membrane Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Proteasomal Protein Catabolic Process Interleukin-23-mediated Signaling Pathway Positive Regulation Of NK T Cell Proliferation CXCL12-activated CXCR4 Signaling Pathway
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