TIMM8A and STAM

Number of citations of the paper that reports this interaction (PMID 12745081)
4

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TIMM8A	STAM
Gene Name		translocase of inner mitochondrial membrane 8 homolog A (yeast)	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space	Cytosol Early Endosome Membrane
	Molecular Function	Metal Ion Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Protein Targeting To Mitochondrion Nervous System Development Cellular Protein Metabolic Process Chaperone-mediated Protein Transport	Intracellular Protein Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		Mitochondrial protein import	Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: KRT15 STAM STAM2 TIMM13	19 interactors: ARRB1 CLTC HGS JAK1 JAK2 JAK3 PJA1 PPP1CA PPP1CC RFFL STAMBP TIMM8A TRIM54 TRIM55 TRIM63 UBC USP15 USP28 USP8
Entrez ID		1678	8027
HPRD ID		02287	03542
Ensembl ID		ENSG00000126953	ENSG00000136738
Uniprot IDs		O60220	Q92783
PDB IDs			2L0A 3F1I 3LDZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endosomal Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Extracellular Vesicular Exosome Assembly Intracellular Transport Chaperone-mediated Protein Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Localization Establishment Of Localization In Cell Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Exocytosis Protein Targeting To Mitochondrion Negative Regulation Of Signal Transduction Protein Localization To Mitochondrion Negative Regulation Of Signaling	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Cellular Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Metabolic Process Regulation Of Proteolysis Signaling Cell Communication Negative Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Modification By Small Protein Removal Cellular Macromolecule Catabolic Process Peptidyl-tyrosine Autophosphorylation Regulation Of Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus STAT Protein Import Into Nucleus Intracellular Transport JAK-STAT Cascade Proteolysis Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Glycogen Metabolic Process Regulation Of Protein Metabolic Process Tyrosine Phosphorylation Of STAT Protein Response To Interleukin-2 Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Polysaccharide Metabolic Process Cellular Response To Organic Substance Cell Cycle Intracellular Protein Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Transport
Tagcloud ?		coil coiled coordinates ddp deafness downs dystonia endosomal endosomes hepatocyte immunoreceptor import imported intermembrane itam jensen localizes mohr optic overlaps pull redistribution ribosomes stam1 tranebjaerg transducing translated ultimately zn	adaptor cloned coil coiled colony conserved counteracts counterpart deleted exogenous granulocyte hepatocyte hrs inducible introduction kda lost macrophage molecularly molecule mutual phosphotyrosine rapidly stimulating stimulation suppressive transducing transduction tyrosine
Tagcloud (Difference) ?		coordinates ddp deafness downs dystonia endosomal endosomes immunoreceptor import imported intermembrane itam jensen localizes mohr optic overlaps pull redistribution ribosomes stam1 tranebjaerg translated ultimately zn	adaptor cloned colony conserved counteracts counterpart deleted exogenous granulocyte hrs inducible introduction kda lost macrophage molecularly molecule mutual phosphotyrosine rapidly stimulating stimulation suppressive transduction tyrosine
Tagcloud (Intersection) ?		coil coiled hepatocyte transducing