RNF34 and UBE2E1

Number of citations of the paper that reports this interaction (PubMedID 35170427)
59

Data Source:
BioGRID (pull down)

		RNF34	UBE2E1
Description		ring finger protein 34	ubiquitin conjugating enzyme E2 E1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endomembrane System Membrane Nuclear Body Nuclear Speck	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol Phosphate Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Cold Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Oxygen Metabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Protein K48-linked Ubiquitination
Pathways		Regulation of TP53 Degradation Antigen processing: Ubiquitination & Proteasome degradation	ISG15 antiviral mechanism Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Academic attainment (English) ( 33594131) Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: APP APPBP2 DNAJA3 FLII IKBKG MAVS MKS1 NOD1 PHF7 RUBCN TRIM23 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2F UBE2H	116 interacting genes: ARIH2 ARK2C ASXL2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 FBXO7 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCHF2 MARCHF3 MARCHF5 MARCHF7 MDM2 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PBX2 POLL POLM PRKN RBX1 RELA RFWD3 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF26 RNF31 RNF34 RNF4 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM3 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM69 TRIM7 UBA1 UBA6 UBA7 UBASH3B UBC UBE2G1 UBE3A UBOX5 UBR5 UBR7 UFM1 USP7 UVSSA WWP2 XIAP ZNG1E ZNRF1 ZNRF2 ZNRF4
Entrez ID		80196	7324
HPRD ID		10509	04225
Ensembl ID		ENSG00000170633	ENSG00000170142
Uniprot IDs		A0A087WTM5 Q969K3	B7Z306 P51965
PDB IDs			1XR9 3BZH 4JJQ 5LBN 6FGA 8IYA
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Innate Immune Response Cytosol ATP Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Protein Modification Process Proteasomal Protein Catabolic Process Proteolysis CARD Domain Binding Positive Regulation Of Interleukin-6 Production Nucleotide Binding Transferase Activity Positive Regulation Of Tumor Necrosis Factor Production Ubiquitin Ligase Complex Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Defense Response To Bacterium Immune System Process Protein Serine/threonine Kinase Binding Regulation Of Canonical NF-kappaB Signal Transduction Protein Catabolic Process Ubiquitin Protein Ligase Activity Regulation Of Autophagy Regulation Of Interleukin-6 Production Response To Other Organism Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Bacterium Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Autophagy Immune Response Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Innate Immune Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Transferase Activity Protein Metabolic Process Zinc Ion Binding Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Metal Ion Binding Macromolecule Metabolic Process Protein Autoubiquitination Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Ubiquitin Ligase Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Response To Stress Regulation Of Post-translational Protein Modification Cytoplasm Positive Regulation Of Catabolic Process Ubiquitin Binding Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Positive Regulation Of Autophagy DNA Damage Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Negative Regulation Of Signal Transduction Innate Immune Response Regulation Of Signal Transduction Immune System Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling
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