RNF34 and MKS1

Number of citations of the paper that reports this interaction (PubMedID 35170427)
59

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, affinity chromatography technology)

		RNF34	MKS1
Description		ring finger protein 34	MKS transition zone complex subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endomembrane System Membrane Nuclear Body Nuclear Speck	Nucleoplasm Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Membrane Ciliary Transition Zone MKS Complex Ciliary Basal Body Cell Projection
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol Phosphate Binding	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Cold Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Oxygen Metabolic Process	Neural Tube Closure Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Left/right Symmetry Regulation Of Smoothened Signaling Pathway Epithelial Structure Maintenance Cell Projection Organization Embryonic Digit Morphogenesis Motile Cilium Assembly Embryonic Skeletal System Development Branching Morphogenesis Of An Epithelial Tube Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Head Development Cardiac Septum Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Common Bile Duct Development Non-motile Cilium Assembly Embryonic Brain Development Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Regulation of TP53 Degradation Antigen processing: Ubiquitination & Proteasome degradation	Hedgehog 'off' state Anchoring of the basal body to the plasma membrane
Drugs
Diseases			Meckel syndrome (MKS); Meckel-Gruber syndrome Bardet-Biedl syndrome (BBS)
GWAS			Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		17 interacting genes: APP APPBP2 DNAJA3 FLII IKBKG MAVS MKS1 NOD1 PHF7 RUBCN TRIM23 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2F UBE2H	3 interacting genes: DDX24 RNF34 TMEM67
Entrez ID		80196	54903
HPRD ID		10509	07900
Ensembl ID		ENSG00000170633	ENSG00000011143
Uniprot IDs		A0A087WTM5 Q969K3	A0A7I2V2M0 B4DVC5 H0Y2S2 J3KSC6 Q9NXB0
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Innate Immune Response Cytosol ATP Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Protein Modification Process Proteasomal Protein Catabolic Process Proteolysis CARD Domain Binding Positive Regulation Of Interleukin-6 Production Nucleotide Binding Transferase Activity Positive Regulation Of Tumor Necrosis Factor Production Ubiquitin Ligase Complex Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Defense Response To Bacterium Immune System Process Protein Serine/threonine Kinase Binding Regulation Of Canonical NF-kappaB Signal Transduction Protein Catabolic Process Ubiquitin Protein Ligase Activity Regulation Of Autophagy Regulation Of Interleukin-6 Production Response To Other Organism Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Bacterium Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Autophagy Immune Response Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Innate Immune Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding	Icosanoid Transmembrane Transporter Activity Glucuronoside Transmembrane Transporter Activity Glucuronoside Transport AV Node Cell To Bundle Of His Cell Signaling Response To Nickel Cation Low Voltage-gated Calcium Channel Activity Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Signaling Macromolecule Catabolic Process Wnt Receptor Catabolic Process Regulation Of Oxygen Metabolic Process Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential ABC-type Bile Acid Transporter Activity SA Node Cell To Atrial Cardiac Muscle Cell Communication AV Node Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential SA Node Cell Action Potential
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