EDC3 and EFHC2

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		EDC3	EFHC2
Description		enhancer of mRNA decapping 3	EF-hand domain containing 2
Image
GO Annotations	Cellular Component	P-body Cytoplasm Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule	Cytoplasm Cytoskeleton Microtubule Axonemal Microtubule Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	RNA Binding MRNA Binding Protein Binding Identical Protein Binding	Calcium Ion Binding Protein Binding
	Biological Process	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA P-body Assembly	Regulation Of Neuron Projection Development Flagellated Sperm Motility Cellular Response To Leukemia Inhibitory Factor
Pathways		mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Mean platelet volume ( 32888494)	Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Glaucoma (primary open-angle) ( 33627673) Mean arterial pressure ( 29403010)
Interacting Genes		11 interacting genes: ANXA10 DDX6 EFHC2 LNX1 MIR15B OGT PIAS2 QARS1 YWHAB YWHAG ZFP36	100 interacting genes: - AASDHPPT ARHGEF5 ARMC7 ATOSB CABP2 CACNB4 CARD9 CCDC102B CCDC120 CCDC13 CCDC57 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CPNE2 CPNE7 CYFIP1 DCLK1 DDX6 DGCR6 DRC7 EDC3 EFHC1 EGLN3 EMD ENKD1 ESRRG EXOC8 EXOSC5 FAM107A FAM124B FAM221B FBXL19 GEM GLYCTK GOLGA1 GPKOW GRB2 GYS1 HDAC4 HGS HNRNPLL INPP5J JAKMIP2 KANK2 KCTD7 KIF9 L3MBTL2 LMNB2 LMO2 LNX1 LONRF1 MAGOHB MAPK9 MID2 MISP MTCL2 MYLIP MYO5B NCDN NCK2 NDOR1 NEK6 NFKBID NME7 NR3C1 PBLD PHF1 PIBF1 PICK1 PLOD3 POLR1C PRPF18 PTK6 QARS1 RAD51D RCOR3 RECK RHOBTB3 RUNX1T1 SNRNP25 SPATA18 SPG21 STK16 TBC1D1 TBC1D22B TEKT4 TRIM42 TRIM50 TSSK3 TUBGCP4 TXK U2AF1 USP2 ZBTB16 ZFHX3 ZZZ3
Entrez ID		80153	80258
HPRD ID		07954	06540
Ensembl ID		ENSG00000179151	ENSG00000183690
Uniprot IDs		Q96F86	Q5JST6
PDB IDs		2VC8 2WAX 2WAY 3D3J 3D3K 6S8S	2Z13 2Z14 7UNG 8J07
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Translation MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Translation Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Metabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Macromolecule Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Negative Regulation Of Metabolic Process Positive Regulation Of Translation Negative Regulation Of Signal Transduction Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Kinase Inhibitor Activity Protein Sequestering Activity Protein Domain Specific Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Concave Side Of Sperm Head Negative Regulation Of Gene Expression Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Negative Regulation Of Polynucleotide Adenylyltransferase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Lysosome TORC1 Signaling Positive Regulation Of TORC1 Signaling Viral RNA Genome Packaging Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Protein-RNA Sequence-specific Adaptor Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction TOR Signaling Translation Positive Regulation Of TOR Signaling P-body Cytoplasmic Stress Granule RISC Complex Negative Regulation Of RNA Metabolic Process Protein Localization To Vacuole Regulation Of TORC1 Signaling Protein Kinase C Inhibitor Activity	Cytoplasm Protein Binding Protein Phosphorylation Cytoskeleton Regulation Of Podosome Assembly Phosphorylation Centrosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?