EDC3 and ZFP36

Number of citations of the paper that reports this interaction (PMID 16364915)
154

Data Source:
HPRD (in vitro, in vivo)

		EDC3	ZFP36
Gene Name		enhancer of mRNA decapping 3	ZFP36 ring finger protein
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytosol Membrane	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	DNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding AU-rich Element Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding MRNA 3'-UTR AU-rich Region Binding Poly(A) RNA Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Gene Expression Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Intracellular Signal Transduction Response To Starvation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	Regulation of mRNA stability by proteins that bind AU-rich elements Tristetraprolin (TTP) destabilizes mRNA
Drugs
Diseases
GWAS		Caffeine consumption ( 21490707)
Protein-Protein Interactions		7 interactors: ANXA10 DCP1B DDX6 EFHC2 YWHAB YWHAG ZFP36	22 interactors: APP CCDC85B CDK6 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 HMGB1 HOXC9 MAPK1 MAPKAPK2 NCL NUP214 SFN UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17
Entrez ID		80153	7538
HPRD ID		07954	01835
Ensembl ID		ENSG00000179151	ENSG00000128016
Uniprot IDs		Q96F86	M0QY76 P26651
PDB IDs		2VC8 2WAX 2WAY 3D3J 3D3K	4J8S
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Aromatic Compound Catabolic Process MRNA Metabolic Process Regulation Of Mitochondrion Organization Negative Regulation Of Cellular Protein Metabolic Process Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Cellular Macromolecule Catabolic Process Negative Regulation Of Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Intracellular Transport Negative Regulation Of Protein Dephosphorylation Response To Insulin Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cellular Response To Peptide Gene Expression Apoptotic Signaling Pathway Cytoplasmic MRNA Processing Body Assembly 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Destabilization Positive Regulation Of Organelle Organization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Targeting Positive Regulation Of MRNA 3'-end Processing Regulation Of Intracellular Transport Regulation Of MRNA 3'-end Processing Response To Peptide Hormone Cellular Response To Organonitrogen Compound Catabolic Process Response To Peptide Positive Regulation Of MRNA Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Cytoplasmic Sequestering Of Protein Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Stabilization Cellular Response To Hormone Stimulus	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway MRNA Catabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway RNA Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Aromatic Compound Catabolic Process Gene Expression Positive Regulation Of Mitochondrion Organization MRNA Metabolic Process RNA Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Cellular Response To Heat Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process System Development Apoptotic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Cell Death Death Cellular Metabolic Process Cellular Response To Heat Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Protein Kinase Activity Developmental Process Nitrogen Compound Metabolic Process Multicellular Organismal Development Regulation Of Kinase Activity Positive Regulation Of Intracellular Transport Innate Immune Response Anatomical Structure Development Positive Regulation Of Signal Transduction Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process Regulation Of Organelle Organization Regulation Of Catalytic Activity Response To Heat Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death
Tagcloud ?		bodies bottom build calorimetry clustering combines crystallography dcp1 dcp2 decapping details foci helical interferes intermolecular isothermal leucine lsm machinery pdc1 pombe prime reconstitute scaffolding schizosaccharomyces titration transitions undergo undetermined	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 ybx1 yy1 zfhx3 zmat3
Tagcloud (Difference) ?		bodies bottom build calorimetry clustering combines crystallography dcp1 dcp2 decapping details foci helical interferes intermolecular isothermal leucine lsm machinery pdc1 pombe prime reconstitute scaffolding schizosaccharomyces titration transitions undergo undetermined	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 ybx1 yy1 zfhx3 zmat3
Tagcloud (Intersection) ?