DSN1 and AIMP2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DSN1	AIMP2
Description		DSN1 component of MIS12 kinetochore complex	aminoacyl tRNA synthetase complex interacting multifunctional protein 2
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Fibrillar Center Extracellular Region Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Nuclear Body Azurophil Granule Lumen	Nucleus Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity Molecular Adaptor Activity
	Biological Process	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Cell Division	Translation Apoptotic Process Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Type II Pneumocyte Differentiation Protein-containing Complex Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Neutrophil degranulation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Factor VII activity ( 30642921) Hallux valgus ( 32131869)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		12 interacting genes: AIMP2 APP CBX3 CBX5 HGS KNL1 MIS12 NSL1 PIK3R3 PMF1 SUGT1 ZWINT	103 interacting genes: AIMP1 APP BCAS2 BEX3 BLOC1S4 BRME1 BYSL C1orf216 CBY2 CEBPA CEP126 CHD3 DARS1 DARS2 DEAF1 DISC1 DRC12 DSN1 EPRS1 EPS8 EXOC8 FGB FHL3 FILNC1 FUBP1 GYS1 ICE1 KARS1 KDR KLC2 KRT31 KRT33B KRT34 KRT36 LMO2 LMO3 LNX1 LUC7L2 MATR3 MCF2L MIR106A MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR15A MIR18A MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR34A MIR34B MIR34C MIR429 MIR451A MIR7-1 MIR7-2 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I MIS18A NDEL1 NECAB2 NTAQ1 PFDN6 PLEKHF2 PPP2R1A PRKAA2 PRKN PSME1 RABEP1 SBK3 SLU7 SMURF2 SPATA18 TANK TCP11 TERF2IP TEX12 TFIP11 TRAF2 TRMT2A ZC3H12A ZGPAT
Entrez ID		79980	7965
HPRD ID		16455	02915
Ensembl ID		ENSG00000149636	ENSG00000106305
Uniprot IDs		A8K3X3 Q9H410	A8MU58 Q13155
PDB IDs		5LSI 5LSJ 5LSK 8PPR 8Q5H	4DPG 4YCU 4YCW 5A1N 5A34 5A5H 5Y6L 6ILD 6IY6 6JPV 6K39 8J9S 9DPL
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Kinetochore Chromosome, Centromeric Region MIS12/MIND Type Complex Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Chromosome Segregation Nuclear Chromosome Segregation Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I Chromosome Organization Chromosome Regulation Of Meiosis I Cell Division Kinetochore Assembly Kinetochore Organization Spindle Pole Pericentric Heterochromatin Regulation Of Meiotic Nuclear Division Cytosol Site Of DNA Damage Heterochromatin Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Meiosis I Spindle Assembly Checkpoint Epigenetic Regulation Of Gene Expression Regulation Of Mitotic Sister Chromatid Separation Regulation Of Meiotic Cell Cycle Positive Regulation Of Neuron Apoptotic Process Organelle Assembly Regulation Of Chromosome Separation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Chromosome Localization Nucleus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Stability Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Cytokine Production Negative Regulation Of Signal Transduction Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Sprouting Angiogenesis Extracellular Space Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility
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