DSN1 and CASC5

Number of citations of the paper that reports this interaction (PMID 15502821)
80

Data Source:
HPRD (in vivo)

		DSN1	CASC5
Gene Name		DSN1, MIS12 kinetochore complex component	cancer susceptibility candidate 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	MIS12/MIND Type Complex Nucleus Cytoplasm Cytosol	Condensed Chromosome Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Division	Mitotic Cell Cycle Acrosome Assembly Nucleosome Assembly Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Phosphatase Activity CENP-A Containing Nucleosome Assembly Protein Localization To Kinetochore Cell Division Spindle Assembly Checkpoint
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AIMP2 APP CASC5 CBX3 CBX5 MIS12 NSL1 PIK3R3 PMF1 SUGT1 ZWINT	6 interactors: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK
Entrez ID		79980	57082
HPRD ID		16455	10634
Ensembl ID		ENSG00000149636	ENSG00000137812
Uniprot IDs		A8K3X3 Q9H410	Q8NG31
PDB IDs			3SI5 4A1G
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Division Chromosome Segregation Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Division Cell Cycle Process Cell Cycle Chromosome Organization Organelle Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Centromere Complex Assembly Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Chromatin Modification Protein-DNA Complex Assembly Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Type II Pneumocyte Differentiation Chromatin Remodeling Intracellular Receptor Signaling Pathway Chromatin Organization	Cell Division Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Chromosome Segregation Mitotic Cell Cycle Process Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Mitotic Nuclear Division Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Cell Cycle Process Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Cell Division Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Catabolic Process Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Organelle Organization Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Glycogen Catabolic Process Protein Localization To Kinetochore
Tagcloud ?		altogether attachment cbf1 cenh3 cenp centromere centromeres centromeric cerevisiae connects cse4 ctf19 inner kinetochore lethality linker mark methylated microtubule mind mtw1 nnf1 nsl1 posttranslational principle r37 saccharomyces segregation termed	13ra2 a12 antigen antigens bage chemo contributing ct ctage1 ddx43 gbm glioblastoma glioma gp100 ihc immunotherapy impressively institute inversely mage mgmt multiforme neoplasia primers rembrandt repository tdrd1 testis verified
Tagcloud (Difference) ?		altogether attachment cbf1 cenh3 cenp centromere centromeres centromeric cerevisiae connects cse4 ctf19 inner kinetochore lethality linker mark methylated microtubule mind mtw1 nnf1 nsl1 posttranslational principle r37 saccharomyces segregation termed	13ra2 a12 antigen antigens bage chemo contributing ct ctage1 ddx43 gbm glioblastoma glioma gp100 ihc immunotherapy impressively institute inversely mage mgmt multiforme neoplasia primers rembrandt repository tdrd1 testis verified
Tagcloud (Intersection) ?