DSN1

Description		DSN1 component of MIS12 kinetochore complex
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Fibrillar Center Extracellular Region Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Nuclear Body Azurophil Granule Lumen
	Molecular Function	Protein Binding
	Biological Process	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Neutrophil degranulation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Factor VII activity ( 30642921) Hallux valgus ( 32131869)
Interacting Genes		12 interacting genes: AIMP2 APP CBX3 CBX5 HGS KNL1 MIS12 NSL1 PIK3R3 PMF1 SUGT1 ZWINT
Entrez ID		79980
HPRD ID		16455
Ensembl ID		ENSG00000149636
Uniprot IDs		A8K3X3 Q9H410
PDB IDs		5LSI 5LSJ 5LSK 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Kinetochore Chromosome, Centromeric Region MIS12/MIND Type Complex Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Chromosome Segregation Nuclear Chromosome Segregation Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I Chromosome Organization Chromosome Regulation Of Meiosis I Cell Division Kinetochore Assembly Kinetochore Organization Spindle Pole Pericentric Heterochromatin Regulation Of Meiotic Nuclear Division Cytosol Site Of DNA Damage Heterochromatin Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Meiosis I Spindle Assembly Checkpoint Epigenetic Regulation Of Gene Expression Regulation Of Mitotic Sister Chromatid Separation Regulation Of Meiotic Cell Cycle Positive Regulation Of Neuron Apoptotic Process Organelle Assembly Regulation Of Chromosome Separation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Chromosome Localization Nucleus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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