TNIP3 and PLSCR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNIP3	PLSCR3
Description		TNFAIP3 interacting protein 3	phospholipid scramblase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Mitochondrion Mitochondrial Inner Membrane Cytosol Plasma Membrane Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding	Magnesium Ion Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Lead Ion Binding Mercury Ion Binding Calcium-dependent Protein Binding
	Biological Process	MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Inflammatory Response Toll-like Receptor 4 Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide	Lipid Transport Apoptotic Process Mitochondrial Membrane Organization Plasma Membrane Phospholipid Scrambling Glucose Homeostasis Cholesterol Homeostasis Regulation Of Apoptotic Process Cellular Response To Lipopolysaccharide Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Breast cancer ( 23468962) Multiple sclerosis ( 31604244)
Interacting Genes		25 interacting genes: CCN3 CYSRT1 DAZAP2 FAM161A KPNA3 KRT40 KRTAP10-3 KRTAP10-8 LITAF LZTS2 MAGEA2 MAGEA2B MTUS2 NBPF19 NOTCH2NLA NTAQ1 PIBF1 PLSCR3 TAX1BP1 TCEANC TNIP1 TRIM55 TRIM63 UBC ZBTB8A	34 interacting genes: ACTMAP AIPL1 C10orf55 C22orf39 CATSPER1 COL8A1 HOXA1 INCA1 KRTAP11-1 KRTAP15-1 KRTAP19-6 KRTAP19-7 KRTAP3-2 KRTAP3-3 KRTAP6-1 LCE1C LCE2B LCE4A LCE5A MAPKBP1 NAA10 NXPE2 PITX1 PLSCR1 PRKCD RUNX1T1 S100A7L2 SMCP STK16 TNIP3 TNS2 TRIP13 WWOX ZIC1
Entrez ID		79931	57048
HPRD ID		16268	07400
Ensembl ID		ENSG00000050730	ENSG00000187838
Uniprot IDs		Q96KP6	Q9NRY6
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Acetylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity	Intermediate Filament Keratinization
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