DNMT3A and UHRF1

  • Number of citations of the paper that reports this interaction (PubMedID 21745816)
  • 54
  • Data Source:
  • BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

DNMT3A

UHRF1

Description DNA methyltransferase 3 alpha ubiquitin like with PHD and ring finger domains 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • A body shape index ( 34021172)
  • Appendicular lean mass ( 33097823)
  • Body mass index ( 26426971)
  • Body mass index (age <50) ( 26426971)
  • Body mass index (age>50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Body size at age 10 ( 32376654)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Crohn's disease ( 21102463 28067908)
  • Heel bone mineral density ( 30598549)
  • Height ( 25282103 31562340 28552196 18391951 25429064)
  • High light scatter reticulocyte count ( 32888494)
  • High light scatter reticulocyte percentage of red cells ( 32888494)
  • Hip circumference adjusted for BMI ( 34021172)
  • Hip index ( 34021172)
  • Inflammatory bowel disease ( 28067908)
  • Lymphocyte count ( 32888494 27863252)
  • Lymphocyte percentage of white cells ( 32888494 27863252)
  • Macular thickness ( 30535121)
  • Multiple sclerosis ( 31604244)
  • Neutrophil percentage of white cells ( 32888494 27863252)
  • Resistant hypertension ( 31545351)
  • Type 1 diabetes ( 21980299)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for BMI in smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)
  • Waist-hip index ( 34021172)
  • Waist-to-hip ratio adjusted for BMI ( 34021172)
  • Age at first sexual intercourse ( 34211149)
  • Appendicular lean mass ( 33097823)
  • Birth weight ( 31043758)
  • Hip circumference adjusted for BMI ( 34021172)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Mental health study participation (completed survey) ( 31263887)
  • Systolic blood pressure ( 30578418)
  • Type 2 diabetes ( 30297969)
  • Urate levels ( 31578528)
Interacting Genes 35 interacting genes: CBX1 CDH1 DDB1 DNMT1 DNMT3B DNMT3L EED EEF1A1 EHMT1 EHMT2 EZH2 F8A1 H3C6 HDAC1 MDFI MEOX2 MYC NRIP1 NUP153 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TERF2IP TP53 UBE2I UHRF1 USP7 ZBTB17 ZBTB18 ZNF513 36 interacting genes: AKT1 ATR DNMT3A ERCC1 ERG FANCD2 FZR1 H2AC4 H2BC3 H3-3A H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 KIF11 LASP1 LIG1 MBD4 MUS81 NR3C1 PCLAF PCNA PLK1 PRKACA SAP30 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UHRF2 USP7
Entrez ID 1788 29128
HPRD ID 04141 06992
Ensembl ID ENSG00000119772 ENSG00000276043
Uniprot IDs A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1 A0A087WVR3 Q96T88
PDB IDs 2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57 6PA7 6W89 6W8B 6W8D 6W8J 8BA5 8QZM 8TDR 8TE1 8TE3 8TE4 8U5H 8UW1 2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW 6VCS 6VED 6VYJ 6W92 7FB7 8JIG 8WMS 8XV4 8XV6 8XV7 8XV8
Enriched GO Terms of Interacting Partners?
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