DNMT3A and EHMT1

Number of citations of the paper that reports this interaction (PMID 22086334)
8

Data Source:
BioGRID (enzymatic study)

		DNMT3A	EHMT1
Gene Name		DNA (cytosine-5-)-methyltransferase 3 alpha	euchromatic histone-lysine N-methyltransferase 1
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Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Euchromatin XY Body Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Nuclear Matrix	Nucleus Nucleoplasm Chromosome Cytoplasm Plasma Membrane
	Molecular Function	DNA Binding Chromatin Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Identical Protein Binding Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates	P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis DNA Methylation On Cytosine Within A CG Sequence Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Hypermethylation Of CpG Island Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Embryo Development Chromatin Modification Histone Methylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Negative Regulation Of Transcription, DNA-templated Histone H3-K9 Methylation Histone H3-K27 Methylation
Pathways		Chromatin modifying enzymes Chromatin organization Epigenetic regulation of gene expression PRC2 methylates histones and DNA RMTs methylate histone arginines DNA methylation	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Height ( 18391951) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		31 interactors: CBX1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 HDAC1 HIST1H3A HIST1H3E MYC NRIP1 PIAS1 PRMT5 PTGES3 RB1 RPS8 SETDB1 SP100 SPI1 SUMO1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18	12 interactors: ATXN1 DNMT3A EED EZH2 HIST1H3A HIST3H3 LZTR1 PCBD1 TP53 TRIM15 UBC WIZ
Entrez ID		1788	79813
HPRD ID		04141	07383
Ensembl ID		ENSG00000119772	ENSG00000181090
Uniprot IDs		Q9Y6K1	Q9H9B1
PDB IDs		2QRV 3A1A 3A1B 3LLR 3SVM	2IGQ 2RFI 3B7B 3B95 3FPD 3HNA 3MO0 3MO2 3MO5 3SW9 3SWC 4I51
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromosome Organization Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Chromatin Modification DNA Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Nucleobase-containing Compound Metabolic Process Methylation DNA Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Gene Expression DNA Metabolic Process Peptidyl-lysine Modification RNA Biosynthetic Process Histone Methylation Regulation Of Metabolic Process Transcription, DNA-templated Histone H3-K9 Modification Protein Methylation Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Histone H3-K9 Methylation Maintenance Of DNA Methylation Cellular Metabolic Process Histone Lysine Methylation Peptidyl-lysine Methylation Chromatin Silencing Peptidyl-amino Acid Modification	Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression, Epigenetic DNA Methylation Chromosome Organization DNA Metabolic Process DNA Modification Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Chromatin Organization DNA Methylation On Cytosine Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Methylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Genetic Imprinting Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Positive Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Rhythmic Process Transcription, DNA-templated Positive Regulation Of Metabolic Process
Tagcloud ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28
Tagcloud (Difference) ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28
Tagcloud (Intersection) ?