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DNMT3A
Description
DNA methyltransferase 3 alpha
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Euchromatin
Heterochromatin
XY Body
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Nuclear Matrix
Catalytic Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
DNA (cytosine-5-)-methyltransferase Activity
Protein Binding
Methyltransferase Activity
Zinc Ion Binding
Transferase Activity
Identical Protein Binding
Unmethylated CpG Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
LncRNA Binding
Protein-cysteine Methyltransferase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
DNA Methylation-dependent Constitutive Heterochromatin Formation
Spermatogenesis
Response To Xenobiotic Stimulus
Response To Toxic Substance
Post-embryonic Development
Response To Ionizing Radiation
Response To Lead Ion
Regulation Of Gene Expression
Neuron Differentiation
Regulatory NcRNA-mediated Heterochromatin Formation
Heterochromatin Formation
Response To Nutrient Levels
Methylation
Response To Estradiol
Response To Vitamin A
Response To Cocaine
Epigenetic Programming Of Gene Expression
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Response To Ethanol
Negative Regulation Of DNA-templated Transcription
Cellular Response To Amino Acid Stimulus
Cellular Response To Ethanol
Cellular Response To Hypoxia
Genomic Imprinting
Hepatocyte Apoptotic Process
Autosome Genomic Imprinting
Transposable Element Silencing By PiRNA-mediated DNA Methylation
Positive Regulation Of Cellular Response To Hypoxia
Cellular Response To Bisphenol A
Pathways
PRC2 methylates histones and DNA
RMTs methylate histone arginines
SUMOylation of DNA methylation proteins
DNA methylation
Defective pyroptosis
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Procaine
Decitabine
Diseases
GWAS
A body shape index (
34021172
)
Appendicular lean mass (
33097823
)
Body mass index (
26426971
)
Body mass index (age <50) (
26426971
)
Body mass index (age>50) (
26426971
)
Body mass index x sex x age interaction (4df test) (
26426971
)
Body size at age 10 (
32376654
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
21102463
28067908
)
Heel bone mineral density (
30598549
)
Height (
25282103
31562340
28552196
18391951
25429064
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Inflammatory bowel disease (
28067908
)
Lymphocyte count (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Macular thickness (
30535121
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
27863252
)
Resistant hypertension (
31545351
)
Type 1 diabetes (
21980299
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for BMI in smokers (
28443625
)
Waist circumference adjusted for body mass index (
28448500
25673412
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Novel Interacting Genes
1 novel interacting genes:
ALK
Interacting Genes
35 interacting genes:
CBX1
CDH1
DDB1
DNMT1
DNMT3B
DNMT3L
EED
EEF1A1
EHMT1
EHMT2
EZH2
F8A1
H3C6
HDAC1
MDFI
MEOX2
MYC
NRIP1
NUP153
PIAS1
PIAS2
PRMT5
PTGES3
SETDB1
SP100
SPI1
SUV39H1
TERF2IP
TP53
UBE2I
UHRF1
USP7
ZBTB17
ZBTB18
ZNF513
Entrez ID
1788
HPRD ID
04141
Ensembl ID
ENSG00000119772
Uniprot IDs
A0A0C4DG02
F8WE91
Q59HC6
Q9Y6K1
PDB IDs
2QRV
3A1A
3A1B
3LLR
3SVM
4QBQ
4QBR
4QBS
4U7P
4U7T
5YX2
6BRR
6F57
6PA7
6W89
6W8B
6W8D
6W8J
8BA5
8QZM
8TDR
8TE1
8TE3
8TE4
8U5H
8UW1
Enriched GO Terms of Interacting Partners
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Epigenetic Regulation Of Gene Expression
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Chromatin Remodeling
Negative Regulation Of Metabolic Process
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Heterochromatin Formation
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Biosynthetic Process
Chromatin Organization
Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Nucleus
DNA Methylation-dependent Constitutive Heterochromatin Formation
Nucleoplasm
Histone H3 Methyltransferase Activity
Heterochromatin
Constitutive Heterochromatin Formation
Histone Methyltransferase Activity
Regulation Of Transcription By RNA Polymerase II
Methylation
Negative Regulation Of Gene Expression
Histone H3K9me2 Methyltransferase Activity
Methyltransferase Activity
Nuclear Body
Histone H3K9 Methyltransferase Activity
DNA Binding
P53 Binding
Epigenetic Programming Of Gene Expression
Promoter-specific Chromatin Binding
Transcription Corepressor Activity
Positive Regulation Of Metabolic Process
Chromatin
Facultative Heterochromatin Formation
Rhythmic Process
Core Promoter Sequence-specific DNA Binding
Transcription Corepressor Binding
Chromosome
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