DNMT3A and F8A1

Number of citations of the paper that reports this interaction (PMID 19139273)
10

Data Source:
BioGRID (enzymatic study)

		DNMT3A	F8A1
Gene Name		DNA (cytosine-5-)-methyltransferase 3 alpha	coagulation factor VIII-associated 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Euchromatin XY Body Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Nuclear Matrix	Nucleus
	Molecular Function	DNA Binding Chromatin Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Identical Protein Binding Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates	Molecular_function
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis DNA Methylation On Cytosine Within A CG Sequence Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Hypermethylation Of CpG Island Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Biological_process
Pathways		Chromatin modifying enzymes Chromatin organization Epigenetic regulation of gene expression PRC2 methylates histones and DNA RMTs methylate histone arginines DNA methylation
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Height ( 18391951) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		31 interactors: CBX1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 HDAC1 HIST1H3A HIST1H3E MYC NRIP1 PIAS1 PRMT5 PTGES3 RB1 RPS8 SETDB1 SP100 SPI1 SUMO1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18	4 interactors: DNMT3A HTT SNTA1 TLR10
Entrez ID		1788	8263
HPRD ID		04141	02374
Ensembl ID		ENSG00000119772	ENSG00000197932
Uniprot IDs		Q9Y6K1	P23610
PDB IDs		2QRV 3A1A 3A1B 3LLR 3SVM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromosome Organization Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Chromatin Modification DNA Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Nucleobase-containing Compound Metabolic Process Methylation DNA Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Gene Expression DNA Metabolic Process Peptidyl-lysine Modification RNA Biosynthetic Process Histone Methylation Regulation Of Metabolic Process Transcription, DNA-templated Histone H3-K9 Modification Protein Methylation Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Histone H3-K9 Methylation Maintenance Of DNA Methylation Cellular Metabolic Process Histone Lysine Methylation Peptidyl-lysine Methylation Chromatin Silencing Peptidyl-amino Acid Modification	Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Cellular Response To Acid Chemical Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Protein Phosphatase Type 2A Activity S-adenosylmethioninamine Metabolic Process Hypermethylation Of CpG Island Quinolinate Biosynthetic Process DNA Methylation On Cytosine Within A CG Sequence Negative Regulation Of Synaptic Transmission, Dopaminergic Cellular Modified Amino Acid Metabolic Process Negative Regulation Of Peptidyl-cysteine S-nitrosylation Lactate Biosynthetic Process Regulation Of Membrane Potential Alpha-amino Acid Metabolic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity C-5 Methylation Of Cytosine Paraxial Mesoderm Formation S-adenosylhomocysteine Metabolic Process Quinolinate Metabolic Process Cellular Response To CGMP Methylation-dependent Chromatin Silencing Response To CGMP Serotonin Transport DNA Methylation Involved In Embryo Development Sperm Ejaculation Neural Plate Morphogenesis L-glutamate Import Citrulline Metabolic Process Lactate Metabolic Process Regulation Of Ion Transmembrane Transport Urea Cycle DNA Methylation On Cytosine Neurotransmitter Uptake Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Urea Metabolic Process Cellular Amino Acid Metabolic Process Cellular Response To Organonitrogen Compound Thalamus Development Striatum Development Spermatogenesis Male Gamete Generation Paraxial Mesoderm Morphogenesis Neural Plate Development Amino Acid Import Insemination Regulation Of Synaptic Transmission, Dopaminergic
Tagcloud ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?