MMRN2 and RHBDD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MMRN2	RHBDD2
Description		multimerin 2	rhomboid domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Extracellular Exosome Multimerin Complex	Golgi Membrane Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Receptor Ligand Activity	Serine-type Endopeptidase Activity Signal Recognition Particle Binding Protein Binding
	Biological Process	Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Signal Transduction Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Morphogenesis Of An Epithelium	Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway
Pathways		O-linked glycosylation
Drugs
Diseases
GWAS			Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		3 interacting genes: CD93 RHBDD2 VDR	60 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NEDD4 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SLC71A3P SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30 YAP1
Entrez ID		79812	57414
HPRD ID		10601	11492
Ensembl ID		ENSG00000173269	ENSG00000005486
Uniprot IDs		Q9H8L6	Q6NTF9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding Nuclear Receptor-mediated Bile Acid Signaling Pathway Apoptotic Process Involved In Mammary Gland Involution Vitamin D Response Element Binding Bile Acid Nuclear Receptor Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Lithocholic Acid Binding Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Vitamin D Binding Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis Complement Component C1q Complex Binding Signal Recognition Particle Binding Regulation Of Phosphate Transport Regulation Of Vitamin D Receptor Signaling Pathway Phosphate Ion Transmembrane Transport Nuclear Retinoid X Receptor Binding Phosphate Ion Transport Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Keratinocyte Proliferation Retinoic Acid Receptor Signaling Pathway Apoptotic Process Involved In Morphogenesis Cell-cell Junction Maintenance Nuclear Steroid Receptor Activity Decidualization Positive Regulation Of Epidermal Cell Differentiation Intestinal Absorption Positive Regulation Of Epidermis Development Maternal Process Involved In Female Pregnancy Apoptotic Process Involved In Development Regulation Of Response To Nutrient Levels Regulation Of Keratinocyte Differentiation Lactation Positive Regulation Of Bone Mineralization MRNA Transcription By RNA Polymerase II Regulation Of Keratinocyte Proliferation Cell Junction Maintenance Nuclear Receptor Activity Positive Regulation Of Biomineral Tissue Development	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Synaptic Transmission, Dopaminergic Mitochondrial Envelope Mitochondrion Organization Apoptotic Signaling Pathway Response To Amphetamine Dopamine Metabolic Process Response To Alkaloid Regulation Of Catecholamine Secretion Protein Binding Response To Amine Membrane Epithelial Cell Proliferation Mitochondrial Membrane Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway Mitochondrial Matrix Catecholamine Catabolic Process Catecholamine Metabolic Process Dopamine Catabolic Process Protein Localization To Mitochondrion
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