CRELD1 and POLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CRELD1	POLA2
Description		CRELD disulfide isomerase 1	DNA polymerase alpha 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Extracellular Matrix Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol Ciliary Basal Body
	Molecular Function	Protein Disulfide Isomerase Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Isomerase Activity	DNA Binding Protein Binding
	Biological Process	Endocardial Cushion Development Cardiac Septum Development	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation Protein Import Into Nucleus
Pathways			Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs			Dacarbazine
Diseases		Atrioventricular septal defect; Atrioventricular canal defect
GWAS		Blood protein levels ( 30072576)	Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		17 interacting genes: ATP5MF COPS6 DRD2 EEF1G EIF6 GDF9 HOXA1 HTR2C KAT5 MAP3K1 MTNR1B NUFIP2 POLA2 PTN SETDB1 SHANK3 ZNF408	33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1
Entrez ID		78987	23649
HPRD ID		06206	10160
Ensembl ID		ENSG00000163703	ENSG00000014138
Uniprot IDs		A0A669KAV0 A0A669KBB3 A0A804HJJ0 A0A804HKP7 Q96HD1	A0A9L9PY44 H0YDR7 Q14181
PDB IDs			2KEB 4E2I 4Y97 5EXR 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Structural Plasticity Regulation Of Long-term Synaptic Potentiation Regulation Of Hormone Secretion Auditory Behavior Cognition Regulation Of Circadian Rhythm Neuromuscular Process Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Long-term Synaptic Potentiation Regulation Of System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Memory Regulation Of Behavior Mechanosensory Behavior Regulation Of Circadian Sleep/wake Cycle Regulation Of Nervous System Process Positive Regulation Of Circadian Rhythm Regulation Of Long-term Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Binding Learning Regulation Of Peptide Hormone Secretion Regulation Of Cell Development Negative Regulation Of Insulin Secretion Regulation Of Neuroblast Proliferation Regulation Of Synaptic Plasticity Positive Regulation Of Cell Development Regulation Of Multicellular Organismal Process Negative Regulation Of Peptide Secretion Semicircular Canal Formation Regulation Of Lipid Biosynthetic Process Assembly Of Large Subunit Precursor Of Preribosome Histone H2AK5 Acetyltransferase Activity Receptor Clustering Regulation Of Neuronal Synaptic Plasticity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Neurogenesis Regulation Of Hormone Levels Ciliary Membrane Visual Behavior G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Differentiation Synapse Negative Regulation Of Sequestering Of Calcium Ion Female Gamete Generation Regulation Of Progesterone Secretion Abducens Nerve Formation Optokinetic Behavior 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	DNA Replication, Synthesis Of Primer Regulation Of Phosphorus Metabolic Process Nucleic Acid Metabolic Process Collateral Sprouting RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Macromolecule Metabolic Process Alpha DNA Polymerase:primase Complex Regulation Of Glycolytic Process
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